High Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosis

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dc.authoridSerin, Ender/0000-0002-0138-6107
dc.contributor.authorYakar, Tolga
dc.contributor.authorDemir, Mehmet
dc.contributor.authorDogan, Ozlem
dc.contributor.authorParlakgumus, Alper
dc.contributor.authorOzer, Birol
dc.contributor.authorSerin, Ender
dc.date.accessioned2024-09-18T21:07:53Z
dc.date.available2024-09-18T21:07:53Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: We aimed to evaluate and compare the efficacy and safety of high-dose furosemide+salt orally by comparing HSS+furosemide (i.v.) and repeated paracentesis in patients with RA. Methods: This was a prospective study of 78 cirrhotic patients with RA, randomized into three groups: Group A (n=25) i.v. furosemide (200-300 mg bid) and 3% hypotonic saline solution (HSS) (once or twice a day); Group B (n= 26) oral furosemide tablets (360-520 mg bid) and salt (2.5 g bid); and, Group C (n= 27) repeated large-volume-paracentesis (RLVP) with albumin infusion. Patients without hyperkalemia were administrated 100 mg of spironolactone/day. During the follow-up; INR, creatinine, and total bilirubin levels were measured to determine the change in MELD (model of end stage liver disease) score. Results: Hepatic encephalopathy (HE), severe episodes of spontaneous bacterial peritonitis (SBP) and pleural effusions (PE) occurred more frequently in Group C. Improvement in Child-Pugh and MELD score was better in Group A and B than Group C. In Group B, improvements were seen in the Child-Pugh and MELD score, reduction in body weight, duration and number of hospitalization. In Groups A and B, remarkable increases in diuresis were observed (706 +/- 116 to 2425 +/- 633 mL and 691 +/- 111 to 2405 +/- 772 mL) and serum sodium levels also improved. HE and SBP were occurred more often in group C (p< 0.002). Hospitalization decreased significantly in Group B (p< 0.001). There was no significant difference in survival among groups. Conclusion: High dose oral furosemide with salt ingestion may be an alternative, effective, safe and well-tolerated method of therapy for RA.en_US
dc.identifier.endpageS60en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue6en_US
dc.identifier.pmid27917812en_US
dc.identifier.startpageS52en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14011
dc.identifier.volume39en_US
dc.identifier.wosWOS:000389725000012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypertonic Saline Solutionsen_US
dc.subjectCongestive-Heart-Failureen_US
dc.subjectRepeated Paracentesisen_US
dc.subjectTense Ascitesen_US
dc.subjectEfficacyen_US
dc.subjectInfusionen_US
dc.subjectAlbuminen_US
dc.subjectModelen_US
dc.subjectMelden_US
dc.titleHigh Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosisen_US
dc.typeArticleen_US

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