Association of MEFV mutations and vascular involvement in Behcet's disease: a study from Hatay, Turkey

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dc.contributor.authorSerarslan, Gamze
dc.contributor.authorCura, Sibel Elmacioglu
dc.contributor.authorKimyon, Gezmis
dc.contributor.authorUcgul, Goekhan
dc.contributor.authorKaradag, Mehmet
dc.date.accessioned2024-09-18T21:00:33Z
dc.date.available2024-09-18T21:00:33Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: In this study, we aimed to determine the frequency of MEFV mutations in Behcet's disease (BD) and to investigate the relationship between clinical findings of the disease and the MEFV mutations. Material and methods: A total of 66 participants (30 BD patients, 36 healthy subjects) were included in this study. The MEFV gene was analyzed by using DNA sequence analysis. Results: The distribution of MEFV mutations was not significantly different between the patients and the control group (p = 0.373). However, individuals with R202Q mutation had a risk of OR 4 times (95% CI: 1.1-14.5) higher than those without the mutation (p = 0.035). The rate of vascular involvement was statistically significantly higher in patients with the mutation than in patients without the mutation (p = 0.005). Conclusions: MEFV mutation was associated with vascular involvement in patients with BD. This is also the first study to indicate that the R202Q mutation may have a role in BD. However large series from different regions are required to compare these results.en_US
dc.description.sponsorshipScientific Research Project Fund of Mustafa Kemal University Faculty of Medicine [19]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Mustafa Kemal University Faculty of Medicine under the project number 19.M.031.en_US
dc.identifier.doi10.5114/reum.2022.117843
dc.identifier.endpage223en_US
dc.identifier.issn0034-6233
dc.identifier.issn2084-9834
dc.identifier.issue3en_US
dc.identifier.pmid35875715en_US
dc.identifier.scopus2-s2.0-85134534191en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://doi.org/10.5114/reum.2022.117843
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12754
dc.identifier.volume60en_US
dc.identifier.wosWOS:000829362800009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofReumatologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectvascularen_US
dc.subjectBehcets diseaseen_US
dc.subjectMEFV mutationen_US
dc.titleAssociation of MEFV mutations and vascular involvement in Behcet's disease: a study from Hatay, Turkeyen_US
dc.typeArticleen_US

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