The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester

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dc.contributor.authorYilmaz, HR
dc.contributor.authorSogut, S
dc.contributor.authorOzyurt, B
dc.contributor.authorOzugurlu, F
dc.contributor.authorSahin, S
dc.contributor.authorIsik, B
dc.contributor.authorUz, E
dc.date.accessioned2024-09-18T19:54:36Z
dc.date.available2024-09-18T19:54:36Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.descriptionSymposium on Clinical Biochemistry and Cancer -- SEP 26-29, 2002 -- Bursa, TURKEYen_US
dc.description.abstractThe aim of this experimental study was to investigate the effects of caffeic acid phenethyl ester (CAPE), an antioxidant agent, on cisplatin-induced hepatotoxicity through adenosine deaminase (AD), xanthine oxidase (XO), catalase (CAT), superoxide dismutase (SOD) activities and malondialdehyde (MDA) and nitric oxide (NO) levels in liver tissue of rats. Wistar albino rats were divided into three groups: control group (n=6), cisplatin group (n=9) and CAPE+cisplatin group (n=8). All the chemicals used were applied intraperitoneally. Spectrophotometric methods were used to determine the activities of the above-mentioned enzymes in the liver tissue. NO level and XO activity were found to be increased in the cisplatin group compared to the control group. NO level was found to be decreased in the cisplatin+CAPE group in comparison with the cisplatin group. There was no significant change in the activity of XO between the cisplatin and cisplatin+CAPE groups. The activity of SOD was lower in the cisplatin group than both the control and cisplatin +CAPE groups. There was no significant change in the activity of CAT between the control and cisplatin groups. CAT activity was increased in the cisplatin+CAPE group compared to the cisplatin group. The AD activity and MDA level remained unchanged in all groups. The results obtained suggested that CAPE significantly attenuated the hepatotoxicity as an indirect target of cisplatin in an animal model of cisplatin-induced nephrotoxicity.en_US
dc.identifier.doi10.1191/0748233705th216oa
dc.identifier.endpage73en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue3-4en_US
dc.identifier.pmid15986578en_US
dc.identifier.scopus2-s2.0-20544463473en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.1191/0748233705th216oa
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7819
dc.identifier.volume21en_US
dc.identifier.wosWOS:000229904800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidant enzymesen_US
dc.subjectCAPEen_US
dc.subjectcisplatinen_US
dc.subjectliveren_US
dc.subjectnitric oxideen_US
dc.titleThe activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl esteren_US
dc.typeConference Objecten_US

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