Investigation of Cytotoxic effects of Oxymetazoline on Lungs in a Rat Mod-el of Rhinitis Medicamentosa

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dc.authoridBOSTANCIKLIOGLU, Mehmet/0000-0001-7169-719X
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorCengiz, Beyhan
dc.contributor.authorBostanciklioglu, Mehmet
dc.contributor.authorDemir, Tuncer
dc.contributor.authorKarabulut, Hayriye
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorUlasli, Mustafa
dc.date.accessioned2024-09-18T20:55:49Z
dc.date.available2024-09-18T20:55:49Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Rhinitis medicamentosa, also known as 'rebound congestion,' is inflammation of the nasal mucosa caused by the overuse of topical nasal decongestants. Although local decongestants resolve the initial nasal obstruction, the overuse causes rebound obstruction. However, how the overuse of the decongestant causes rhinitis medicamentosa is not known. Objectives: Here, we show the intracellular effects of oxymetazoline, commonly used a local decongestant, on the cell death pathways. We also investigated the antioxidative effects of erdosteine suspension (175 mg/5mL), an antioxidative agent. Methods: Thirty Wistar-albino rats were used to form the rhinitis medicamentosa model. After rhinitis medicamentosa was clinically detected, we removed the whole lungs of animals to perform the molecular analyses of cell death pathways. Results: We found a statistically significant decrease in the expression levels of Atg5 (p=0.021), Atg7 (p=0.013) and Ulk1 (p=0.036) in the oxymetazoline group compared to the control group (p<0.05); however, Caspase 3 expression level was recorded to be significantly increased in the oxymetazoline group, and the expression level of Beclin1 recorded to be substantially increased in the erdosteine group (p=0.001). Conclusion: Based on these grounds, we suggest that vasoconstriction in capillary vessels caused by oxymetazoline could lead to a decrease in the blood supply, which triggers autophagy to ensure cellular homeostasis.en_US
dc.identifier.doi10.2174/1874467213666200727124105
dc.identifier.endpage666en_US
dc.identifier.issn1874-4672
dc.identifier.issn1874-4702
dc.identifier.issue4en_US
dc.identifier.pmid32718303en_US
dc.identifier.startpage658en_US
dc.identifier.urihttps://doi.org/10.2174/1874467213666200727124105
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12062
dc.identifier.volume14en_US
dc.identifier.wosWOS:000701795900003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Molecular Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRhinitis medicamentosaen_US
dc.subjectautophagyen_US
dc.subjectapoptosisen_US
dc.subjectoxymetazolineen_US
dc.subjectlocal decongestionsen_US
dc.subjecterdosteineen_US
dc.titleInvestigation of Cytotoxic effects of Oxymetazoline on Lungs in a Rat Mod-el of Rhinitis Medicamentosaen_US
dc.typeArticleen_US

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