Pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid in rainbow trout (Oncorhynchus mykiss)

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dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorMarin, Pedro
dc.contributor.authorAcar, Omer Faruk
dc.contributor.authorAksoy, Mert
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-09-18T20:04:26Z
dc.date.available2024-09-18T20:04:26Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Although research on the mechanism and control of pain and inflammation in fish has increased in recent years, the use of analgesic drugs is limited due to the lack of pharmacological information about analgesic drugs. Tolfenamic acid is a nonsteroidal anti-inflammatory drug and can be used in fish due to its low side effect profile and superior pharmacokinetic properties. Objectives: The pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acidwere investigated following single intravascular (IV), intramuscular (IM) and oral administration of 2 mg/kg in rainbow trout at 13 +/- 0.5 degrees C. Methods: The experiment was carried out on a total of 234 rainbow trout (Oncorhynchus mykiss). Tolfenamic acid was administered to fish via IV, IM and oral route at a dose of 2 mg/kg. Blood samples were taken at 13 different sampling times until the 72 h after drug administration. The plasma concentrations of tolfenamic acid were quantified using high pressure liquid chromatography-ultraviolet (UV) and pharmacokinetic parameters were assessed using non-compartmental analysis. Results: The elimination half-life (t1/2 lambda z) of tolfenamic acid for IV, IM and oral routes was 3.47, 6.75 and 9.19 h, respectively. For the IV route, the volume of distribution at a steady state and total body clearance of tolfenamic acid were 0.09 L/kg and 0.03 L/h/kg, respectively. The peak plasma concentration and bioavailability for IM and oral administration were 8.82 and 1.24 mu g/mL, and 78.45% and 21.48%, respectively. Themean plasma protein binding ratio of tolfenamic acid in rainbow trout was 99.48% and was not concentration dependent. Conclusions: While IM route, which exhibits both the high plasma concentration and bioavailability, can be used in rainbow trout, oral route is not recommended due to low plasma concentration and bioavailability. However, there is a need to demonstrate the pharmacodynamic activity of tolfenamic acid in rainbow trout.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye [2209-A, 1919B012108881]en_US
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkiye, Grant / Award Numbers: 2209 -A., 1919B012108881).en_US
dc.identifier.doi10.1002/vms3.1533
dc.identifier.issn2053-1095
dc.identifier.issue4en_US
dc.identifier.pmid38952278en_US
dc.identifier.urihttps://doi.org/10.1002/vms3.1533
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8166
dc.identifier.volume10en_US
dc.identifier.wosWOS:001260319600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofVeterinary Medicine and Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbioavailabilityen_US
dc.subjectpharmacokineticsen_US
dc.subjectplasma protein bindingen_US
dc.subjectrainbow trouten_US
dc.subjecttolfenamic aciden_US
dc.titlePharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid in rainbow trout (Oncorhynchus mykiss)en_US
dc.typeArticleen_US

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