Proanthocyanidin alleviates testicular torsion/detorsion-induced ischemia/ reperfusion injury in rats

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dc.authoridAkcakavak, Gokhan/0000-0001-5949-4752
dc.contributor.authorKazak, Filiz
dc.contributor.authorAkcakavak, Gokhan
dc.contributor.authorAlakus, Ibrahim
dc.contributor.authorAlakus, Halil
dc.contributor.authorKirgiz, Omer
dc.contributor.authorKaratas, Ozhan
dc.contributor.authorDeveci, Mehmet Zeki Yilmaz
dc.date.accessioned2024-09-18T20:53:03Z
dc.date.available2024-09-18T20:53:03Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTesticular torsion is an urological emergency and can lead to ischemia damage and testicular loss if not diagnosed in time. Proanthocyanidin is reported to have anti-inflammatory and antioxidant properties. The current study aimed to examine the possible effects of proanthocyanidin (P) on the testis in torsion/detorsion (T/D)induced testicular ischemia/reperfusion (I/R) injury in rats. Forty rats were divided into four groups (n=10 for each): sham-operated (sham), I/R, I/R + P100 (100 mg/kg, 30 min before torsion), and I/R + P200 (200 mg/kg, 30 min before torsion). Testicular T/D was performed on the left testicle by 3 hours of torsion at 720 degrees clockwise, followed by 3 hours of detorsion. In the I/R group, an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH), vitamin C (Vit C), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PD) values were determined compared to the sham group (p <0.001). Moreover, an increase in the expression of cleaved caspase-3 and Bcl2-associated X protein (Bax), a decrease in the expression of B-cell lymphoma 2 (Bcl2) and proliferating cell nuclear antigen (PCNA) were detected in the I/R group (p <0.001). Histopathologically, it was determined that the Johnsen and Cosentino scores of the testicles were irregular in the I/R group (p <0.001). Proanthocyanidin treatment caused a decrease in MDA, cleaved caspase-3 and Bax levels and an increase in GSH, Vit C, GPx, G6PD, Bcl-2 and PCNA values. Additionally, Johnsen and Cosentino rearranged the scores. The present findings revealed the protective and curative effects of proanthocyanidin in organ damage due to testicular torsion/detorsion-induced ischemia/reperfusion with their antioxidative and antiapoptotic properties.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Research Fund [22.GAP.026]en_US
dc.description.sponsorshipThis study was supported by the Hatay Mustafa Kemal University Research Fund (22.GAP.026) .en_US
dc.identifier.doi10.1016/j.tice.2024.102459
dc.identifier.issn0040-8166
dc.identifier.pmid39002290en_US
dc.identifier.scopus2-s2.0-85198270454en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.tice.2024.102459
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11552
dc.identifier.volume89en_US
dc.identifier.wosWOS:001272673800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofTissue & Cellen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative stressen_US
dc.subjectBaxen_US
dc.subjectBcl-2en_US
dc.subjectCleaved caspase-3en_US
dc.subjectProanthocyanidinen_US
dc.subjectTorsion/detorsionen_US
dc.titleProanthocyanidin alleviates testicular torsion/detorsion-induced ischemia/ reperfusion injury in ratsen_US
dc.typeArticleen_US

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