Orchiectomy or testosterone receptor blockade reduces intestinal mucosal damage caused by ischemia-reperfusion insult

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dc.authoridTEMIZ, ABDULKERIM/0000-0001-8789-6003
dc.contributor.authorAkcora, Buelent
dc.contributor.authorAltug, Enes
dc.contributor.authorKontas, Tuenay
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorTemiz, Abdulkerim
dc.date.accessioned2024-09-18T20:28:10Z
dc.date.available2024-09-18T20:28:10Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate whether orchiectomy or administration of flutamide an antagonist of the testosterone receptor can reduce oxidative stress and histologic damage in the rat small bowel subjected to mesenteric ischemia/reperfusion (I/R) injury. A total of 32 Sprague-Dawley rats were divided into four groups. Group 1 was control (sham), group 2 was I/R, group 3 was I/R plus orchiectomy (orchiectomy was performed 14 days before I/R), group 4 was I/R plus flutamide (flutamide was given throughout 14 days before mesenteric IR). Rats were subjected to 45 min of mesenteric ischemia followed by 3 h of reperfusion. The levels of ileal malondialdehyde (MDA) and nitric oxide (NO) were found to be significantly lower in orchiectomy and flutamide treatment groups compared with I/R group (P < 0.05). The histopathological injury scores were consistent with the MDA and NO levels. These results suggest that castration or testosterone receptor blockade decreases the level of intestinal I/R injury in male rats and it is an another example for disease variations based on gender differences.en_US
dc.identifier.doi10.1007/s00383-007-2062-z
dc.identifier.endpage341en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue3en_US
dc.identifier.pmid17973111en_US
dc.identifier.scopus2-s2.0-43149100142en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-007-2062-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10775
dc.identifier.volume24en_US
dc.identifier.wosWOS:000253483600017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjectbowelen_US
dc.subjectorchiectomyen_US
dc.subjectflutamideen_US
dc.titleOrchiectomy or testosterone receptor blockade reduces intestinal mucosal damage caused by ischemia-reperfusion insulten_US
dc.typeArticleen_US

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