Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia

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dc.authoridCiftciler, Rafiye/0000-0001-5687-8531
dc.authoridErdal, Huseyin/0000-0003-0786-5077
dc.contributor.authorErdal, Huseyin
dc.contributor.authorCiftciler, Rafiye
dc.contributor.authorTuncer, Sibel Cigdem
dc.contributor.authorOzcan, Oguzhan
dc.date.accessioned2024-09-18T20:53:02Z
dc.date.available2024-09-18T20:53:02Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis is the first study to evaluate both the dynamic thiol-disulfide homeostasis and ischemia-modified albumin (IMA) levels in patients with chronic lymphocytic leukemia (CLL). Twenty-nine patients with CLL and 20 controls were included in the study. The dynamic thiol-disulfide balance was determined by the newly developed colorimetric method by Erel. IMA levels were determined by the cobalt binding test. We found that total antioxidant status levels were lower while total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly higher in patients with CLL than controls. Moreover, native and total thiol levels were found to be statistically significant between the study and control groups (p<0.001), whereas no statistically significant difference was noted for IMA levels (p=0.365). A negative correlation was observed between native and total thiol levels, leukocyte, lymphocyte, and TOS. Total bilirubin showed positive correlation with direct bilirubin and alkaline phosphatase. In addition, IMA levels showed a positive correlation with OSI. This study highlights measurement of native and total thiol and IMA levels in patients with CLL for the first time. Dynamic thiol-disulfide homeostasis may contribute in the pathophysiological mechanism, and follow-up to disease in patients with CLL.en_US
dc.identifier.doi10.1136/jim-2022-002568
dc.identifier.endpage66en_US
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue1en_US
dc.identifier.pmid36038148en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://doi.org/10.1136/jim-2022-002568
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11551
dc.identifier.volume71en_US
dc.identifier.wosWOS:000848648700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectoxidantsen_US
dc.subjectleukemiaen_US
dc.subjecthematologyen_US
dc.subjecthematologic diseasesen_US
dc.titleEvaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemiaen_US
dc.typeArticleen_US

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