Protective effect of ebselen on experimental testicular torsion and detorsion injury

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dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.authorid, ahmet/0000-0001-6274-5700
dc.contributor.authorRifaioglu, M. M.
dc.contributor.authorMotor, S.
dc.contributor.authorDavarci, I.
dc.contributor.authorTuzcu, K.
dc.contributor.authorSefil, F.
dc.contributor.authorDavarci, M.
dc.contributor.authorNacar, A.
dc.date.accessioned2024-09-18T20:15:07Z
dc.date.available2024-09-18T20:15:07Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEbselen is used as a drug in clinical trials against stroke, reperfusion injury with anti-atherosclerotic and renoprotective effects. The aim of this study is to investigate the protective effect of ebselen, on torsion/detorsion (T/D)-induced biochemical and histopathological changes in experimental testicular ischaemia/reperfusion injury. A total of 28 male Wistar Albino rats were divided into four groups: group 1(sham-operated group, n=7), group 2(ebselen group, n=7), group 3(torsion/detorsion + saline, n=7) and group 4(T/D+10mgkg(-1) ebselen group, n=7). The tissue homogenate samples were used for immediate nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase, catalase and glutathione measurement. Testes in all groups were evaluated for the biochemical assay and histopathological examinations. To evaluate spermatogenesis, Johnsen scoring system was used. Testicular tissue MDA and NO levels in group 3 were significantly higher than in group 1 and 4. In histological evaluation of the testicular tissues, ebselen administration improved tubular histology significantly compared with T/D group. Significant increase in histological score was observed in the testis of group 3 compared with group 1 and 2. Histological score in group 4 significantly decreased compared with group 3. Johnson score was significantly lower in T/D group compared with all other three groups, ebselen administration increased the score significantly compared with T/D group. Ebselen reduced oxidative biochemical and histopathological damage in our testicular T/D rat model.en_US
dc.identifier.doi10.1111/and.12204
dc.identifier.endpage1140en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue10en_US
dc.identifier.pmid25388506en_US
dc.identifier.scopus2-s2.0-84920288668en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1134en_US
dc.identifier.urihttps://doi.org/10.1111/and.12204
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9459
dc.identifier.volume46en_US
dc.identifier.wosWOS:000344913900008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDetorsionen_US
dc.subjectebselenen_US
dc.subjectraten_US
dc.subjecttestisen_US
dc.subjecttorsionen_US
dc.titleProtective effect of ebselen on experimental testicular torsion and detorsion injuryen_US
dc.typeArticleen_US

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