Changes in selected immunological parameters and oxidative stress responses in different organs of Oncorhynchus mykiss exposed to ivermectin
[ N/A ]
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Syscom 18 SRL
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, effects of ivermectin on selected immunological parameters, oxidative stress, and antioxidant status in the blood, liver, kidney, heart, and spleen of the rainbow trout (Oncorhynchus mykiss) were examined. Ivermectin was administered intraperitoneally at single doses of 0.01 and 0.02 mg ivermectin kg-1 fish. Blood and tissue samples (liver, kidney, heart, and spleen) were then removed on days 3, 7,10, and 14 for immunological and biochemical analyses. The immunological parameters measured were numbers of leucocytes (WBC), nitroblue tetrazolium activity (NBT), total plasma protein (TP), and total immunoglobulin (TI). Malondialdehyde (MDA) values were measured in the liver, kidney, heart, and spleen tissues as indexes of oxidation, and the activities of catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were measured as indexes of antioxidant status. The results showed a decrease in the WBC value, NBT activity, and TP and Tl levels after the injection of 0.01 and 0.02 mg ivermectin kg1 fish (p <0.05, 0.01, 0.001). Our results suggest that ivermectin at these doses causes oxidation in fish liver, kidney, heart, and spleen tissues due to impairment of the antioxidant system.
Açıklama
Anahtar Kelimeler
Antioxidant status, Antiparasitic drug, Immunological parameter, Ivermectin, Oxidative stress, Pesticide, Rainbow trout
Kaynak
Revista de Chimie
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
63
Sayı
10
