Synthesis, characterization and electrochemistry studies of iron(III) complex with curcumin ligand

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dc.authoridOzbolat, Guluzar/0000-0002-3487-1088
dc.contributor.authorOzbolat, Guluzar
dc.contributor.authorYegani, Arash Alizadeh
dc.contributor.authorTuli, Abdullah
dc.date.accessioned2024-09-18T20:11:39Z
dc.date.available2024-09-18T20:11:39Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIron overload is a serious clinical condition for humans and is a key target in drug development. The aim of this study was to investigate the coordination of iron(III) ions with curcumin ligand that may be used in the treatment of iron overload. Iron(III) complex of curcumin was synthesized and structurally characterized in its solid and solution state by FT-IR, UV-Vis, elemental analysis, and magnetic susceptibility. Electrochemical behaviour of the ligand and the complexes were examined using cyclic voltammetry. The cytotoxic activities of the ligand and the iron(III) complex were evaluated by the MTT assay. Curcumin reacted with iron in high concentrations at physiological pH at room temperature. Subsequently, a brown-red complex was formed. Data regarding magnetic susceptibility showed that the complexes with a 1:2 (metal/ligand) mole ratio had octahedral geometry. The complex showed higher anti-oxidant effect towards the cell line ECV304 at IC50 values of 4.83 compared to curcumin. The complex exhibited very high cytotoxic activity and showed a cytotoxic effect that was much better than that of the ligand. The potentials for redox were calculated as 0.180V and 0.350V, respectively. The electrochemistry studies showed that Fe3+/Fe2+ couple redox process occurred at low potentials. This value was within the range of compounds that are expected to show superoxide dismutase activity. This finding indicates that the iron complex is capable of removing free radicals. The observed cytotoxicity could be pursued to obtain a potential drug. Further studies investigating the use of curcumin for this purpose are needed.en_US
dc.identifier.doi10.1111/1440-1681.12964
dc.identifier.endpage1226en_US
dc.identifier.issn0305-1870
dc.identifier.issn1440-1681
dc.identifier.issue11en_US
dc.identifier.pmid29751366en_US
dc.identifier.scopus2-s2.0-85055335905en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1221en_US
dc.identifier.urihttps://doi.org/10.1111/1440-1681.12964
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9003
dc.identifier.volume45en_US
dc.identifier.wosWOS:000448269100015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcomplexen_US
dc.subjectcurcuminen_US
dc.subjectcyclic voltammetryen_US
dc.subjectiron overloaden_US
dc.subjectliganden_US
dc.subjectMTTen_US
dc.titleSynthesis, characterization and electrochemistry studies of iron(III) complex with curcumin liganden_US
dc.typeArticleen_US

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