Prognostic value of Prognostic Nutritional Index (PNI) for 5-year recurrence-free survival in surgically resected gastrointestinal stromal tumors

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dc.contributor.authorDuymus, Mehmet Esat
dc.contributor.authorUgur, Mustafa
dc.contributor.authorDal, Mehmet Burak
dc.contributor.authorAslan, Ersin Rasim
dc.contributor.authorDonmez, Yasemin
dc.contributor.authorOzgur, Tumay
dc.contributor.authorSecinti, Ilke Evrim
dc.date.accessioned2024-09-18T20:25:23Z
dc.date.available2024-09-18T20:25:23Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND: Recent studies have investigated the role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), and prognostic nutritional index (PNI) on prognosis for various malig-nancies. However, the value of these markers in determining the prognosis for gastrointestinal stromal tumors (GIST) remains controversial. We investigated the effect of NLR, PLR, SII, and PNI on 5-year recurrence-free survival (RFS) in patients with surgically resected GIST. MATERIALS AND METHODS: We retrospectively analyzed patients (n=47) who had undergone surgical resection for pri-mary, localized GIST at a single institution between 2010 and 2021. The patients were divided into two groups accord-ing to the recurrence status in the 5-year period as 5-year RFS(+) (patients with no recurrence (n=25) and 5-year RFS(-) (patients with recurrence (n=22) groups. RESULTS: In univariate analyses, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), tumor localiza-tion, tumor size, PNI, and risk category were significantly different between the RFS(+) and RFS(-) groups while NLR, PLR, SII were not. Multivariate analyses revealed that only the tumor size (HR =5.485, 95% CI: 0.210-143.266, p=0.016), and PNI (HR= 112.020, 95% CI: 8.755-1433.278, p<0.001) were independent prognostic factors for RFS. The patients with a high PNI (>= 46.25) had a higher 5-year RFS rate than the patients with low PNI (<46.25) (95.2% to 19.2%, p<0.001). CONCLUSION: A higher preoperative PNI is an independent positive predictor for 5-year RFS for patients with surgi-cally resected GIST. However, NLR, PLR, and SII have no significant effect.en_US
dc.identifier.endpage26en_US
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue1en_US
dc.identifier.pmid36810307en_US
dc.identifier.scopus2-s2.0-85148773011en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10275
dc.identifier.volume94en_US
dc.identifier.wosWOS:000978892100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.relation.ispartofAnnali Italiani Di Chirurgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGISTen_US
dc.subjectPrognostic Nutritional Indexen_US
dc.subjectPrognostic Markeren_US
dc.titlePrognostic value of Prognostic Nutritional Index (PNI) for 5-year recurrence-free survival in surgically resected gastrointestinal stromal tumorsen_US
dc.typeArticleen_US

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