Serum periostin levels in COVID-19: Is it useful as a new biomarker?

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dc.authoridcabalak, mehmet/0000-0003-1148-2247
dc.authoriddikmen, nursel/0000-0002-5923-400X
dc.contributor.authorCabalak, Mehmet
dc.contributor.authorDogan, Serdar
dc.contributor.authorBal, Tayibe
dc.contributor.authorDikmen, Nursel
dc.date.accessioned2024-09-18T21:05:14Z
dc.date.available2024-09-18T21:05:14Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives Severe disease characterised by interstitial pneumonia may develop in some cases of coronavirus disease (COVID-19). Periostin has been associated with many respiratory diseases. In this study, we aimed to investigate whether periostin could be a useful new biomarker in the follow-up and severity assessment of the disease in patients with COVID-19 pneumonia. Methods In the study, 32 patients followed up during May to July 2020 because of COVID-19 and 24 healthy controls were included. The patients were divided into two groups, namely, mild/moderate and severe, according to the severity of the disease. Serum periostin and transforming growth factor beta (TGF-beta) levels were tested using an enzyme-linked immunosorbent assay (ELISA) method using commercially available ELISA kits. Results It was observed that the periostin level was significantly higher in both mild/moderate cases and severe cases compared with the control group at first presentation. However, TGF-beta levels at first presentation were similar between the groups. Conclusions The current manuscript may be the first one performing periostin ELISA on COVID serum, and we believe that periostin can be used as a new biomarker.en_US
dc.identifier.doi10.1111/ijcp.14728
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue11en_US
dc.identifier.pmid34396648en_US
dc.identifier.scopus2-s2.0-85113144143en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.14728
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13463
dc.identifier.volume75en_US
dc.identifier.wosWOS:000686948000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Hindawien_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProteinen_US
dc.titleSerum periostin levels in COVID-19: Is it useful as a new biomarker?en_US
dc.typeArticleen_US

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