Calorie restriction modulates hippocampal NMDA receptors in diet-induced obese rats

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dc.authoridDELIBAS, NAMIK/0000-0001-8014-6189
dc.authoridDelibas, Namik/0000-0002-1354-8927
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorVural, Huseyin
dc.contributor.authorYilmaz, Mustafa
dc.contributor.authorSutcu, Recep
dc.contributor.authorSirmali, Rana
dc.contributor.authorHicyilmaz, Hicran
dc.contributor.authorDelibas, Namik
dc.date.accessioned2024-09-18T20:06:23Z
dc.date.available2024-09-18T20:06:23Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCalorie restriction (CR) has attracted increased interest since CR enhances lifespan and alters age-related decline in hippocampal-dependent cognitive functions. Obesity is associated with poor neurocognitive outcome including impaired hippocampal synaptic plasticity and cognitive abilities such as learning and memory. N-Methyl-D-aspartate receptors (NMDARs) are linked to hippocampal-dependent learning and memory, which may be stabilized by CR. In the present study, we aimed to establish the effects of CR on NMDARs in CA1 region of hippocampus in obese and non-obese rats. In addition, malondialdehyde (MDA) levels were determined as a marker for lipid peroxidation (LPO) in hippocampus. Four groups were constituted as control group (C, n = 9), obese group (OB, n = 10), obese calorie-restricted group (OCR, n = 9), and non-obese calorie-restricted group (NCR, n = 10). OCR and NCR were fed with a 60% CR diet for 10 weeks. After 10 weeks of CR, the MDA levels significantly decreased in the calorie-restricted groups. Obesity caused significant decreases in NR2A and NR2B subunit expressions in the hippocampus. The hippocampal NR2A and NR2B levels significantly increased in the OCR group compared with the OB group (P < 0.05). In contrast, the hippocampal NR2A and NR2B levels significantly decreased in the NCR group compared with the C group (P < 0.05). Oxidative stress can be prevented by CR, and these data may provide a molecular and cellular mechanism by which CR may regulate NMDAR-mediated response against obesity-induced changes in the hippocampus.en_US
dc.description.sponsorshipScientific Research Project Unit of Suleyman Demirel University [BAP-TU-1367]en_US
dc.description.sponsorshipThe study was supported by the Scientific Research Project Unit of Suleyman Demirel University (BAP-TU-1367). The authors confirm that they have no other conflict of interest.en_US
dc.identifier.doi10.3109/10799893.2011.569724
dc.identifier.endpage219en_US
dc.identifier.issn1079-9893
dc.identifier.issn1532-4281
dc.identifier.issue3en_US
dc.identifier.pmid21470075en_US
dc.identifier.scopus2-s2.0-79957854039en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.3109/10799893.2011.569724
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8494
dc.identifier.volume31en_US
dc.identifier.wosWOS:000291034900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Receptors and Signal Transductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalorie restrictionen_US
dc.subjectobesityen_US
dc.subjectNMDARen_US
dc.subjecthippocampusen_US
dc.subjectlipid peroxidationen_US
dc.titleCalorie restriction modulates hippocampal NMDA receptors in diet-induced obese ratsen_US
dc.typeArticleen_US

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