In vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis model

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dc.authoridTerzi, Menderes Yusuf/0000-0001-8478-0451
dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorTerzi, Menderes Yusuf
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorDogan, Serdar
dc.contributor.authorKalacı, Aydıner
dc.date.accessioned2024-09-18T20:52:59Z
dc.date.available2024-09-18T20:52:59Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOsteoarthritis (OA) is a degenerative disease affecting the majority of over 65 year old people and characterized by cartilage degeneration, subchondral abnormal changes, and inflammation. Despite the enormous socioeconomic burden caused by OA, currently, there is no effective therapy against it. Upper zone of growth plate and cartilage matrix associated protein (UCMA) is a vitamin K dependent protein and has a critical role in pathophysiological conditions associated with bone and cartilage. However, there is no research on the protective role of intra-articular UCMA treatment in OA pathogenesis. Therefore, we aimed to investigate the potential therapeutic role of UCMA in an in vivo model of OA. We report for the first time that intra-articular UCMA injection ameliorated cartilage degeneration in a monosodium iodoacetate induced OA rat model. Furthermore, the OA-induced activation of nuclear factor kappa B and bone morphogenetic protein 2 signals was attenuated by UCMA. Our results indicated that UCMA decreased cartilage oligomeric matrix protein levels but did not affect interleukin 6, total antioxidant status, and total oxidant status levels in the serum. In conclusion, UCMA exhibited a therapeutic potential in the treatment of OA. This protective effect of UCMA is possibly achieved by reducing the aggrecanase activity and the production of inflammatory cytokines.en_US
dc.description.sponsorshipScientific Research Project Fund of Hatay Mustafa Kemal Universityen_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Hatay Mustafa Kemal University. Author contributions: H.M.O. conceived and designed the study. H.M.O., M.Y.T., I..K., S.D., and A.K. wrote/drafted/edited the manuscript and interpreted the results. H.M.O., M.Y.T., I..K., S.D., and A.K. performed experiments and laboratory analysis. H.M.O., M.Y.T., I..K., and S.D. conducted analyses, prepared graphs/figures, and revised the manuscript.en_US
dc.identifier.doi10.1139/cjpp-2020-0009
dc.identifier.endpage770en_US
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.issue11en_US
dc.identifier.pmid32640182en_US
dc.identifier.scopus2-s2.0-85095771848en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage763en_US
dc.identifier.urihttps://doi.org/10.1139/cjpp-2020-0009
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11520
dc.identifier.volume98en_US
dc.identifier.wosWOS:000589887900003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Science Publishingen_US
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectosteoarthritisen_US
dc.subjectUCMAen_US
dc.subjectcartilage degenerationen_US
dc.subjectoxidative stressen_US
dc.subjectmonosodium iodoacetateen_US
dc.subjectrat osteoarthritis modelen_US
dc.subjecttotal antioxidant statusen_US
dc.subjecttotal oxidant statusen_US
dc.titleIn vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis modelen_US
dc.typeArticleen_US

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