Neurological soft signs as the stroke risk in sickle cell disease

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dc.authoridDUMAN, Taskin/0000-0002-6552-4193
dc.contributor.authorMelek, Ismet
dc.contributor.authorAkgul, Ferit
dc.contributor.authorDuman, Taskin
dc.contributor.authorYalcin, Fatih
dc.contributor.authorGali, Edip
dc.date.accessioned2024-09-18T20:57:03Z
dc.date.available2024-09-18T20:57:03Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSickle cell disease (SCD) is a common form of hemoglobinopathy and is highly prevalent worldwide. Silent cerebral infarction, which represents infarction without clinical signs, is a risk factor for clinical stroke in patients with SCD. It is well known that silent infarction predisposes patients with SCD to overt stroke. The aim of the present study is to investigate the effect of silent infarction on neurological soft signs (NSS), which demonstrate subtle impairments in sensory integration, motor coordination and the sequencing of complex motor acts and to evaluate whether NSS can be used in clinical practice to evaluate the patients at risk of stroke in SCD patients with silent infarction. Fifty-nine SCD patients without any documented history of cerebrovascular accident and 28 healthy controls were included in this study. All the patients with SCD were evaluated with cerebral magnetic resonance imaging. We found that the NSS scores were significantly higher in patients with silent cerebral infarction than those in patients without silent infarction and control subjects (p < 0.05). Importantly, there was no significant difference in the NSS scores between the patients without silent infarction and control subjects. These results indicate that high NSS scores represnt an important finding for diagnosis of silent infarction in SCD patients. As silent infarction increases the risk for stroke in patients with SCD, NSS can be used to provide additional information in diagnosis of the patients with possible stroke risk during the course of SCD.en_US
dc.identifier.doi10.1620/tjem.209.135
dc.identifier.endpage140en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue2en_US
dc.identifier.pmid16707855en_US
dc.identifier.scopus2-s2.0-33646761337en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.209.135
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12257
dc.identifier.volume209en_US
dc.identifier.wosWOS:000237541800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsickle cellen_US
dc.subjectcerebral infarctionen_US
dc.subjectsoft signsen_US
dc.titleNeurological soft signs as the stroke risk in sickle cell diseaseen_US
dc.typeArticleen_US

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