Effect of Xylazine on Pharmacokinetics and Physiological Efficacy of Intravenous Carprofen in Castrated Goats Kids

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dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridTURK, ERDINC/0000-0003-1735-1774
dc.authoridDingil, Hasan Basri/0000-0001-5212-4804
dc.contributor.authorUney, Kamil
dc.contributor.authorYuksel, Murat
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorCoskun, Devran
dc.contributor.authorTurk, Erdinc
dc.contributor.authorDingil, Hasan Basri
dc.contributor.authorCorum, Orhan
dc.date.accessioned2024-09-18T20:08:04Z
dc.date.available2024-09-18T20:08:04Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCarprofen can be used in the castration process of male goats due to its low side effects, long elimination half-life, and long-term effect. However, no studies were found on the pharmacokinetics and physiological efficacy of carprofen when employed for castration in male goats. The aim of this study was to determine the effect of xylazine (0.05 mg/kg, intramuscular) on the pharmacokinetics and physiological efficacy following intravenous administration of carprofen (4 mg/kg, intravenous) in male goat kids castrated using the burdizzo method. Thirty male Kilis goat kids (5-6 months and 18-30 kg of body weight) were randomly assigned to five groups (n = 6) as follows: healthy control (HC), castration control (CAST), castration+carprofen (CAST+CRP), castration+xylazine (CAST+XYL), and castration+xylazine+carprofen (CAST+XYL+CRP). Plasma concentrations of carprofen were analyzed via a non-compartmental method. Physiological parameters including serum cortisol, scrotal temperature, rectal temperature, and scrotal circumference were determined. Xylazine caused a decrease in the volume of distribution and clearance and an increase in the area under the curve of carprofen in CAST+XYL+CRP group (p < 0.05). The mean cortisol concentrations in CAST+CRP and CAST+XYL remained lower compared to CAST (p < 0.05). The mean cortisol concentrations in CAST+XYL+CRP were lower than in CAST+CRP and CAST+XYL (p < 0.05). In addition, the effect of carprofen administration alone on reducing the initial cortisol response to castration was observed from 6 to 48 h, while in combination with xylazine, it was observed immediately up to 48 h. No treatment differences were observed in rectal temperature, scrotal temperature, and scrotal circumference (p > 0.05). Xylazine caused an increase in plasma concentration and a decrease in clearance of carprofen after co-administration. However, when the effect of the combined administration of carprofen with xylazine on cortisol is evaluated, their combined use in castration process may be beneficial.en_US
dc.identifier.doi10.3390/ani13172700
dc.identifier.issn2076-2615
dc.identifier.issue17en_US
dc.identifier.pmid37684964en_US
dc.identifier.urihttps://doi.org/10.3390/ani13172700
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8601
dc.identifier.volume13en_US
dc.identifier.wosWOS:001065317700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofAnimalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcastrationen_US
dc.subjectcarprofenen_US
dc.subjectcortisolen_US
dc.subjectpharmacokineticsen_US
dc.subjectxylazineen_US
dc.titleEffect of Xylazine on Pharmacokinetics and Physiological Efficacy of Intravenous Carprofen in Castrated Goats Kidsen_US
dc.typeArticleen_US

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