The Protective Role of Urtica dioica Seed Extract Against Azoxymethane-Induced Colon Carcinogenesis in Rats

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dc.authoridYENER, Zabit/0000-0002-6365-5843
dc.authoridUyar, Ahmet/0000-0003-4345-6756
dc.authoriddogan, abdulahad/0000-0002-5438-8560
dc.contributor.authorUyar, Ahmet
dc.contributor.authorDogan, Abdulahad
dc.contributor.authorYaman, Turan
dc.contributor.authorKeles, Omer Faruk
dc.contributor.authorYener, Zabit
dc.contributor.authorCelik, Ismail
dc.contributor.authorAlkan, Elif Ebru
dc.date.accessioned2024-09-18T21:05:06Z
dc.date.available2024-09-18T21:05:06Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the protective role of Urtica dioica seed (UDS) extract against azoxymethane (AOM)-induced colon carcinogenesis in rats. Thirty-two male Wistar albino rats were divided into four groups: Control, AOM, AOM + UDS, and UDS. The AOM and AOM + UDS groups were induced by AOM (15 mg/kg body weight) subcutaneously once a week for 10 weeks. AOM + UDS and UDS groups additionally received fed with pellets included 30 ml/kg UDS extract. At the end of the trial, blood and colon tissue samples were taken from the rats following necropsy. The gross and histopathological findings revealed that the administration of UDS extract significantly decreased lesions including aberrant cript foci, adenoma, and adenocarcinoma formation both numerically and dimensionally. Immunohistochemically, slight CEA and COX-2, strong Caspase-3 immune-expressions were detected in the group AOM + UDS compared to AOM group. Biochemical examinations indicated that a markedly increase in the malondialdehyde and fluctuated antioxidant defense system constituents levels such as reduced glutathione, glutathione s-transferase, glutathione peroxidase, superoxide dismutase were restored in AOM + UDS group. These results reveal that the UDS may act as a chemopreventive dietary agent, inducing apoptosis, resulting in a significant reduction of colon carcinogenesis.en_US
dc.description.sponsorshipYuzuncu Yil University Scientific Research Projects Foundation [2015-VF-B082]en_US
dc.description.sponsorshipThis research was supported by the Yuzuncu Yil University Scientific Research Projects Foundation (Grant number 2015-VF-B082).en_US
dc.identifier.doi10.1080/01635581.2021.1881568
dc.identifier.endpage319en_US
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.issue1en_US
dc.identifier.pmid33560145en_US
dc.identifier.scopus2-s2.0-85100712588en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage306en_US
dc.identifier.urihttps://doi.org/10.1080/01635581.2021.1881568
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13372
dc.identifier.volume74en_US
dc.identifier.wosWOS:000616570900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoutledge Journals, Taylor & Francis Ltden_US
dc.relation.ispartofNutrition and Cancer-An International Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal-Canceren_US
dc.titleThe Protective Role of Urtica dioica Seed Extract Against Azoxymethane-Induced Colon Carcinogenesis in Ratsen_US
dc.typeArticleen_US

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