Preventive effect of rolipram, a phosphodiesterase 4 enzyme inhibitor, on oxidative renal injury in acute ascending pyelonephritis model in rats

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dc.authoridGORUR, Sadik/0000-0002-3458-5428
dc.contributor.authorGoeruer, Sadik
dc.contributor.authorCelik, Sefa
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorAslanta, Oezkan
dc.contributor.authorErdogan, Suat
dc.contributor.authorAydin, Muhsin
dc.contributor.authorOcak, Sabahattin
dc.date.accessioned2024-09-18T21:03:11Z
dc.date.available2024-09-18T21:03:11Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVES To evaluate the effects of rolipram, a phosphodiesterase 4 enzyme inhibitor, on Escherichia coli-induced renal oxidative damage in an acute pyelonephritis (PYN) rat model. METHODS A total of 35 male Wistar albino rats were randomly divided into 7 groups (n = 5) as follows: control (uninfected), PYN 24 hours, PYN 48 hours, PYN 72 hours, PYN + rolipram 24 hours, PYN + rolipram 48 hours, and PYN + rolipram 72 hours. Ascending PYN was induced in the study groups by E. coli inoculation into the bladder, and the urethras were then occluded by collodium for 4 hours. Rolipram injections (1 mg/kg) were started before bacterial inoculation and repeated at 24-hour intervals in the PYN + rolipram groups until death. The rats were killed at the indicated times. Malondialdehyde and nitric oxide levels and superoxide dismutase and catalase activities were determined in kidney homogenates. Histopathologic examinations were also performed. RESULTS Tissue malondialdehyde and nitric oxide levels and superoxide dismutase and catalase activities were significantly increased in the kidneys from the PYN groups. However, rolipram administration reduced renal malondialdehyde and nitric oxide levels and enhanced superoxide dismutase and catalase activities. The histopathologic examinations demonstrated that rolipram treatment reduced the inflammation grade in the kidney specimens. CONCLUSIONS The results of our study have shown that rolipram has a protective effect on renal tissue from E. coli-induced oxidative injury. Therefore, phosphodiesterase 4 inhibitors might be a novel therapeutic option for the prevention and/or management of acute PYN.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Project Commission [06 T 1101]en_US
dc.description.sponsorshipThis study was supported by the Mustafa Kemal University Scientific Research Project Commission (project 06 T 1101).en_US
dc.identifier.doi10.1016/j.urology.2008.04.013
dc.identifier.endpage748en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue4en_US
dc.identifier.pmid18554698en_US
dc.identifier.scopus2-s2.0-52949118486en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage743en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2008.04.013
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13292
dc.identifier.volume72en_US
dc.identifier.wosWOS:000259845600005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectScarring Following Infectionen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectEscherichia-Colien_US
dc.subjectPde4 Inhibitorsen_US
dc.subjectIschemiaen_US
dc.subjectSuperoxideen_US
dc.titlePreventive effect of rolipram, a phosphodiesterase 4 enzyme inhibitor, on oxidative renal injury in acute ascending pyelonephritis model in ratsen_US
dc.typeArticleen_US

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