Serum Uric Acid, Inflammation, and Nondipping Circadian Pattern in Essential Hypertension

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dc.authoridOzcan, Firat/0000-0002-7954-7839
dc.authoridSokmen, Erdogan/0000-0002-8170-5912
dc.authoridTasoglu, Irfan/0000-0001-7714-0296
dc.contributor.authorTurak, Osman
dc.contributor.authorOzcan, Firat
dc.contributor.authorTok, Derya
dc.contributor.authorIsleyen, Ahmet
dc.contributor.authorSokmen, Erdogan
dc.contributor.authorTasoglu, Irfan
dc.contributor.authorAydogdu, Sinan
dc.date.accessioned2024-09-18T21:05:23Z
dc.date.available2024-09-18T21:05:23Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractUric acid (UA) is independently associated with the emergence of hypertension. Nocturnal nondipping pattern of hypertension is associated with a greater risk of cardiovascular, renal, and cerebrovascular complications than dippers. The aim of the present study was to evaluate the relationship between the circadian blood pressure rhythm and UA level in patients with newly diagnosed essential hypertension. The study included 112 essential hypertensive patients and 50 healthy controls. The hypertensive patients were divided into two groups according to the results of 24-hour ambulatory blood pressure monitoring, including 60 dippers (35 men, 25 women; mean age, 52.6 +/- 15.8 years) and 52 nondippers (29 men, 23 women; mean age, 55.9 +/- 13.2 years). Nondippers had significantly higher serum UA levels than the dippers and controls (5.8 +/- 0.8, 5.1 +/- 0.9 and 4.2 +/- 0.9 mg/dL, respectively; P<.001). Serum high-sensitivity C-reactive protein levels were also significantly higher in the nondipper group than the other groups (P<.001) and significantly correlated with serum UA (r=0.358, P<.001). Multivariate logistic regression analysis revealed an independent positive association between serum UA levels and nondipper pattern (odds ratio, 2.28; 95% confidence interval, 1.333.94; P=.003). Serum UA is strongly and independently associated with the nondipper circadian pattern in essential hypertension.en_US
dc.identifier.doi10.1111/jch.12026
dc.identifier.endpage13en_US
dc.identifier.issn1524-6175
dc.identifier.issn1751-7176
dc.identifier.issue1en_US
dc.identifier.pmid23282120en_US
dc.identifier.scopus2-s2.0-84871874055en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1111/jch.12026
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13544
dc.identifier.volume15en_US
dc.identifier.wosWOS:000312993600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElevated Blood-Pressureen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectCell-Proliferationen_US
dc.subjectHyperuricemiaen_US
dc.subjectRisken_US
dc.subjectAssociationen_US
dc.subjectAllopurinolen_US
dc.subjectPopulationen_US
dc.subjectPredictorsen_US
dc.subjectPreventionen_US
dc.titleSerum Uric Acid, Inflammation, and Nondipping Circadian Pattern in Essential Hypertensionen_US
dc.typeArticleen_US

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