Comparison of serum nitric oxide, malondialdehyde levels, and antioxidant enzyme activities in Behcet's disease with and without ocular disease

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dc.contributor.authorAydin, E
dc.contributor.authorSögüt , S
dc.contributor.authorÖzyurt, H
dc.contributor.authorÖzugurlu, F
dc.contributor.authorAkyol, Ö
dc.date.accessioned2024-09-18T20:04:22Z
dc.date.available2024-09-18T20:04:22Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The pathogenesis of Behcet's disease ( BD) may be related to excessive production of reactive oxygen species, activated neutrophils, and T lymphocytes. The goal of this prospective study was to investigate whether there is any relationship among the oxidant/ antioxidant system and nitric oxide ( NO) and malondialdehyde (MDA) levels in patients with BD and its subtypes: complete Behcet's disease (CBD) and incomplete Behcet's disease (ICBD), with or without ocular disease. Methods: Thirty-two patients and 26 age- and sex-matched healthy control subjects were evaluated for NO and MDA levels and antioxidant enzyme activities. The patients with BD were divided into two subgroups: those with and without ocular disease. Twelve patients with CBD and 4 patients with ICBD had ocular disease. The serum NO level was determined by Griess reaction. The MDA level was detected by thiobarbituric acid reaction. Superoxide dismutase ( SOD) and glutathione peroxidase (GSH-Px) activities in serum were analyzed with spectrophotometric methods. Results: Increased MDA levels but decreased GSH-Px activities in plasma were observed in BD patients with all subtypes, as compared with controls. Concerning the presence of ocular disease and the subtype ( CBD or ICBD) compared with each other, there were no significant differences in MDA or NO serum levels and SOD or GSH-Px enzyme activities. Conclusions: Serum NO levels and SOD enzyme activities were not significantly changed in patients with BD and its subtypes; however, a remarkable decrease of GSH-Px enzyme activity and increase of MDA levels were found. Copyright (C) 2004 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000077332
dc.identifier.endpage182en_US
dc.identifier.issn0030-3747
dc.identifier.issn1423-0259
dc.identifier.issue3en_US
dc.identifier.pmid15103210en_US
dc.identifier.scopus2-s2.0-2342477268en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://doi.org/10.1159/000077332
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8120
dc.identifier.volume36en_US
dc.identifier.wosWOS:000220973300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOphthalmic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectnitric oxideen_US
dc.subjectmalondialdehydeen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectglutathione peroxidaseen_US
dc.titleComparison of serum nitric oxide, malondialdehyde levels, and antioxidant enzyme activities in Behcet's disease with and without ocular diseaseen_US
dc.typeArticleen_US

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