Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis

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dc.authoridIYIGUN, Ufuk/0000-0002-6693-8822
dc.contributor.authorBalci, D. D.
dc.contributor.authorBalci, A.
dc.contributor.authorKarazincir, S.
dc.contributor.authorUcar, E.
dc.contributor.authorIyigun, U.
dc.contributor.authorYalcin, F.
dc.contributor.authorSeyfeli, E.
dc.date.accessioned2024-09-18T20:02:43Z
dc.date.available2024-09-18T20:02:43Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPsoriasis is associated with an increased risk of atherosclerosis. This study compared subclinical atherosclerosis of the carotid and brachial arteries in psoriasis vulgaris patients and healthy controls using high-resolution ultrasonography. We studied 43 psoriasis patients and 43 healthy controls matched for age and sex. Flow-mediated dilatation (FMD) and nitroglycerin-induced dilatation (NTD) of the brachial artery and intima-media thickness (IMT) of the common carotid arteries (CCA) were measured ultrasonographically. Diabetes mellitus, hypertension, renal failure, a history of cardiovascular or cerebrovascular disease were exclusion criteria. Subjects who were receiving lipid-lowering therapy, antihypertensive or anti-aggregant drugs, nitrates or long-term systemic steroids were also excluded. The mean IMT values of the right, left and averaged CCA of the psoriasis patients were significantly higher, compared with the controls (0.607 +/- 0.144 mm vs. 0.532 +/- 0.101 mm, 0.611 +/- 0.157 mm vs. 0.521 +/- 0.117 mm, and 0.609 +/- 0.146 mm vs. 0.526 +/- 0.104 mm; P = 0.006, P = 0.003 and P = 0.003, respectively). The mean FMD and NTD values of the psoriasis patients were significantly lower, compared with the controls (13.36 +/- 6.39 mm vs. 19.60 +/- 11.23 mm and 21.08 +/- 8.38 mm vs. 26.85 +/- 12.38 mm; P = 0.002 and P = 0.013, respectively). Multiple linear regression analysis revealed a significant association between psoriasis and the IMT, FMD and NTD. Moreover, the FMD in psoriasis patients was associated with disease duration. Psoriasis patients had impaired endothelial function and thicker IMT of the CCA, compared with the healthy control subjects. The presence of psoriasis was an independent risk factor for subclinical atherosclerosis.None declared.en_US
dc.identifier.doi10.1111/j.1468-3083.2008.02936.x
dc.identifier.endpage6en_US
dc.identifier.issn0926-9959
dc.identifier.issn1468-3083
dc.identifier.issue1en_US
dc.identifier.pmid18702627en_US
dc.identifier.scopus2-s2.0-57649192846en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1111/j.1468-3083.2008.02936.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7988
dc.identifier.volume23en_US
dc.identifier.wosWOS:000261715900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of The European Academy of Dermatology and Venereologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectatherosclerosisen_US
dc.subjectcarotid intima-media thicknessen_US
dc.subjectendothelial functionen_US
dc.subjectpsoriasisen_US
dc.titleIncreased carotid artery intima-media thickness and impaired endothelial function in psoriasisen_US
dc.typeArticleen_US

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