Causative pathogens and antibiotic resistance in diabetic foot infections: A prospective multi-center study

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dc.authoridaltay, fatma aybala/0000-0002-7149-2968
dc.authoridhatipoglu, mustafa/0000-0001-9910-1650
dc.authoridCelik, Ilhami/0000-0002-2604-3776
dc.authoridyanik yalcin, tugba/0000-0001-5996-8639
dc.authoridEryilmaz-Eren, Esma/0000-0002-2712-9694
dc.authoridHosoglu, Salih/0000-0002-4034-9202
dc.authoridAydin, Ozlem/0000-0003-0398-9216
dc.contributor.authorHatipoglu, Mustafa
dc.contributor.authorMutluoglu, Mesut
dc.contributor.authorTurhan, Vedat
dc.contributor.authorUzun, Gunalp
dc.contributor.authorLipsky, Benjamin A.
dc.contributor.authorSevim, Erol
dc.contributor.authorDemiraslan, Hayati
dc.date.accessioned2024-09-18T19:54:29Z
dc.date.available2024-09-18T19:54:29Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Clinical practice guidelines for the management of diabetic foot infections developed by the Infectious Diseases Society of America (IDSA) are commonly used worldwide. The issue of whether or not these guidelines need to be adjusted for local circumstances, however, has seldom been assessed in large prospective trials. Methods: The Turk-DAY trial was a prospective, multi-center study in which infectious disease specialists from centers across Turkey were invited to participate (NCT02026830). Results: A total of 35 centers throughout Turkey enrolled patients in the trial. Overall, investigators collected a total of 522 specimens from infected diabetic foot wounds for culture from 447 individual patients. Among all isolates, 36.4% were gram-positive organisms, with Staphylococcus aureus the most common among these (11.4%). Gram-negative organisms constituted 60.2% of all the isolates, and the most commonly isolated gram-negative was Escherichia coli (15%). The sensitivity rates of the isolated species were remarkably low for several antimicrobials used in the mild infection group. Conclusions: Based on our findings, several of the antimicrobials frequently used for empirical treatment, including some also recommended in the IDSA guidelines, would not be optimal for treating diabetic foot infections in Turkey. Although the IDSA guideline recommendations may be helpful to guide empiric antimicrobial therapy of DFIs, they should be adjusted to local conditions. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jdiacomp.2016.02.013
dc.identifier.endpage916en_US
dc.identifier.issn1056-8727
dc.identifier.issn1873-460X
dc.identifier.issue5en_US
dc.identifier.pmid26965794en_US
dc.identifier.scopus2-s2.0-84959521823en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage910en_US
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2016.02.013
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7762
dc.identifier.volume30en_US
dc.identifier.wosWOS:000378759700027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Diabetes and Its Complicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibiotic therapyen_US
dc.subjectDiabetic footen_US
dc.subjectGuidelineen_US
dc.subjectInfectionen_US
dc.subjectTurkeyen_US
dc.titleCausative pathogens and antibiotic resistance in diabetic foot infections: A prospective multi-center studyen_US
dc.typeArticleen_US

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