Investigation of hepatoprotective effect of some algae species on carbon tetrachloride-induced liver injury in rats

Basit Öğe Kaydı
dc.authoridYipel, Mustafa/0000-0002-6390-9313
dc.authoridAltinok-Yipel, Fulya/0000-0001-8577-2031
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoridTekeli, Ibrahim Ozan/0000-0002-6845-2279
dc.contributor.authorAltinok-Yipel, F.
dc.contributor.authorTekeli, I. O.
dc.contributor.authorOzsoy, S. Y.
dc.contributor.authorGuvenc, M.
dc.contributor.authorSayin, S.
dc.contributor.authorYipel, M.
dc.date.accessioned2024-09-18T19:52:34Z
dc.date.available2024-09-18T19:52:34Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate hepatoprotective effect of some algae species such as Spirulina platensis, Chlorella vulgaris, Laminaria japonica, Sargassum sp. on experimental acute hepatotoxicity model that induced with carbon tetrachloride (CCl4) in rats. Algaes at a dose of 200 mg/kg and Silymarin at a dose of 25 mg/kg were orally administered for 7 days followed by CCl4 at a single dose (0.5 ml/kg), at the 8th day to cause experimental acute hepatotoxicity. Levels of biochemical (AST, ALT etc.), lipid peroxidation (MDA), antioxidant (GSH, CAT, GPx) parameters and histopathological examination were carried out to investigate the hepatoprotective effects of algae. In Sp group ALT and ALP levels were significantly decreased compared with CCl4 (p < .05). Histological liver structures of Sp group were similar to the control group. MDA, GPx and CAT levels of Sp and La groups were significantly different compared with CCl4 (p < .05). Based on these results, algae species able to minimise the toxic effects of CCl4 and especially S. platensis could be used in the purpose of protection against chemical-induced hepatotoxicity.en_US
dc.description.sponsorshipScientific Research Projects Coordination of Mustafa Kemal University [:14660]en_US
dc.description.sponsorshipThis work was financially supported by Scientific Research Projects Coordination of Mustafa Kemal University (Project no:14660).en_US
dc.identifier.doi10.1080/13813455.2019.1702062
dc.identifier.endpage467en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue5en_US
dc.identifier.pmid31855071en_US
dc.identifier.scopus2-s2.0-85076934247en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage463en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2019.1702062
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7524
dc.identifier.volume126en_US
dc.identifier.wosWOS:000503535000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlgaeen_US
dc.subjecthepatoprotective effecten_US
dc.subjectcarbon tetrachlorideen_US
dc.subjectoxidative stressen_US
dc.titleInvestigation of hepatoprotective effect of some algae species on carbon tetrachloride-induced liver injury in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
7524.pdf
Boyut:
908.82 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu