Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice

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dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.contributor.authorOktar, Sueleyman
dc.contributor.authorGokce, Ahmet
dc.contributor.authorAydin, Mehmet
dc.contributor.authorDavarci, Muersel
dc.contributor.authorMeydan, Sedat
dc.contributor.authorOzturk, Oktay Hasan
dc.contributor.authorKoc, Ahmet
dc.date.accessioned2024-09-18T20:19:49Z
dc.date.available2024-09-18T20:19:49Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractMethotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate can cause serious or life-threatening side effects on liver, lungs, kidneys, and immune system. Methotrexate chemotherapy causes testicular damage in humans. The aim of this study was to investigate the possible protective role of erdosteine on testicular toxicity of methotrexate in mice. Twenty-six male mice were divided into four groups as follows: group 1, control; group 2, erdosteine-treated; group 3, methotrexate-treated; and group 4, methotrexate + erdosteine treated. On the first day of experiment, a single dose of methotrexate was intraperitoneally administered to groups 3 and 4, although a daily single dose of erdosteine was orally administered to group 2 and 4 for 7 days. At the end of the experiment, the testes of the animals were removed and weighed. The levels of total antioxidant capacity and total oxidative stress, and myeloperoxidase activity in the methotrexate group were higher than the control group (p<0.05). Lipid peroxidation levels were not changed in methotrexate group compared with control group. In conclusion, erdosteine could effectively protect the testes in methotrexate-induced toxicity.en_US
dc.identifier.doi10.1177/0748233710369666
dc.identifier.endpage438en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue7en_US
dc.identifier.pmid20504824en_US
dc.identifier.scopus2-s2.0-77955459120en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage433en_US
dc.identifier.urihttps://doi.org/10.1177/0748233710369666
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9879
dc.identifier.volume26en_US
dc.identifier.wosWOS:000280645400005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterdosteineen_US
dc.subjecttestesen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidant capacityen_US
dc.subjectmethotrexateen_US
dc.titleBeneficial effect of erdosteine on methotrexate-induced testicular toxicity in miceen_US
dc.typeArticleen_US

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