Diazinon-induced brain toxicity and protection by vitamins E plus C

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dc.contributor.authorYilmaz, Nigar
dc.contributor.authorYilmaz, Mustafa
dc.contributor.authorAltuntas, Irfan
dc.date.accessioned2024-09-18T20:15:11Z
dc.date.available2024-09-18T20:15:11Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractDiazinon (DI) is a widely used pesticide in agriculture, resulting in environmental deleterious effects on neural systems. The current study was performed to investigate the effects of treatment with vitamins E plus C on brain toxicity, which is possibly induced by DI. Twenty-one male rats were divided into three groups (n = 7/group) as follows: (1) control group (C); (2) DI-treated group (DI); (3) DI + vitamins E plus C-treated group (DI + Vit). In order to examine lipid peroxidation and antioxidant status in rats, the level of malondialdehyde (MDA), activities of two free radical scavanging enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) have been studied in brain of rat. The results showed that treatment with DI induced significant (p < 0.05) increases in the level of serum MDA in rat brain. The vitamins E plus C combination reduced lipid peroxidation in rat brain. The activity of SOD level was significantly higher in DI + Vit group, compared to the control group. GSH-Px, SOD and CAT values were not significantly different in the DI group than in control. Oxidative stress contributes to DI-induced brain toxicity. Our results suggested that vitamins E plus C combination may have a protective effect on DI-induced brain toxicity.en_US
dc.identifier.doi10.1177/0748233711404035
dc.identifier.endpage57en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue1en_US
dc.identifier.pmid21543467en_US
dc.identifier.scopus2-s2.0-84856477416en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.1177/0748233711404035
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9502
dc.identifier.volume28en_US
dc.identifier.wosWOS:000299577400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiazinonen_US
dc.subjectlipid peroxidationen_US
dc.subjectantioxidant statusen_US
dc.subjectbrainen_US
dc.subjectvitamin Een_US
dc.subjectvitamin Cen_US
dc.titleDiazinon-induced brain toxicity and protection by vitamins E plus Cen_US
dc.typeArticleen_US

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