Skin diseases in patients with ?-thalassemia major

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dc.contributor.authorDogramaci, Asena Cigdem
dc.contributor.authorSavas, Nazan
dc.contributor.authorOzer, Burcin
dc.contributor.authorDuran, Nizami
dc.date.accessioned2024-09-18T21:05:16Z
dc.date.available2024-09-18T21:05:16Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground beta-Thalassemia major affects multiple organs and is associated with considerable morbidity and mortality. The goal of this analysis was to document the frequency of skin diseases among patients with beta-thalassemia major. Methods A sample of 78 patients with beta-thalassemia major was recruited and interviewed at the thalassemia clinic between April and June 2008. A dermatologist completed a skin examination of each patient and recorded any skin disease present. The patients' laboratory results and treatment modalities were recorded from the charts. Results Sixty-five (83.3%) of the 78 patients examined had a diagnosed skin disease: pruritus (37.2%), xerosis (34.6%), scars (24.4%), ephelides (23.1%), skin irritation/erythema caused by deferoxamine pump (12.8%), idiopathic guttate hypomelanosis (6.4%), pityriasis alba (6.4%), tinea infections (5.1%), verruca vulgaris (5.1%), urticaria (3.8%), hyperhidrosis, contact dermatitis, and acne (2.6%), necrobiosis lipoidica (1.3%), melasma (1.3%), and others (14.1%). Pruritus and xerosis increased in frequency with age. The mean serum ferritin level was higher in patients with xerosis than in those without (5607.7 +/- 2997.5 ng/mL and 4285.2 +/- 4732.4 ng/mL, respectively) (P = 0.005). Moreover, xerosis was observed significantly more frequently in patients using deferoxamine and deferiprone than in those using deferasirox (P = 0.047, P = 0.027, and P = 0.273, respectively). Conclusion Skin diseases, especially pruritus and xerosis, are observed highly frequently in patients with beta-thalassemia major. Treatment is needed for these patients who already have other significant morbidities.en_US
dc.identifier.doi10.1111/j.1365-4632.2009.04176.x
dc.identifier.endpage1061en_US
dc.identifier.issn0011-9059
dc.identifier.issn1365-4632
dc.identifier.issue10en_US
dc.identifier.pmid19785086en_US
dc.identifier.scopus2-s2.0-70349495514en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1057en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-4632.2009.04176.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13487
dc.identifier.volume48en_US
dc.identifier.wosWOS:000269977200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPseudoxanthoma-Elasticumen_US
dc.subjectMorbidityen_US
dc.subjectLesionsen_US
dc.titleSkin diseases in patients with ?-thalassemia majoren_US
dc.typeArticleen_US

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