Quantitative Brain Diffusion-Tensor MRI Findings in Patients With Sickle Cell Disease

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dc.contributor.authorBalcı, Ali
dc.contributor.authorKarazincir, Sinem
dc.contributor.authorBeyoglu, Yeliz
dc.contributor.authorCingiz, Cihangir
dc.contributor.authorDavran, Ramazan
dc.contributor.authorGali, Edip
dc.contributor.authorOkuyucu, Esra
dc.date.accessioned2024-09-18T20:13:22Z
dc.date.available2024-09-18T20:13:22Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE. The aim of this study was to evaluate the microstructure of various regions of the brain using diffusion-tensor imaging (DTI) in patients with sickle cell disease (SCD) and in age- and sex-matched healthy control subjects. We also investigated the fiber tractography findings of the corpus callosum (CC) and corticospinal tracts (CSTs). SUBJECTS AND METHODS. Sixteen right-handed patients with SCD and 14 age- and sex-matched right-handed healthy control subjects were scanned using conventional MR sequences and DTI. Fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) were calculated and regions of interest were selected in various brain areas (superior and inferior frontal, parietal, occipital, and temporal white matter areas), anterior and posterior periventricular areas, centrum semiovale, basal ganglia (lentiform nucleus, head of caudate nucleus), thalamus, cerebral peduncles, pons, cerebellar white matter areas, and CC. Diffusion-tensor tractography of the CC and CSTs was also performed. RESULTS. For the patients with SCD, significantly reduced FA values, increased ADC values, or both were seen clustered in several brain areas, including the CC, frontal white matter, centrum semiovale, periventricular areas, head of the caudate nucleus, thalamus, brainstem, and pons (p < 0.05). Statistically significant reductions in fiber counts in the first and fifth segments of the CC and in CSTs bilaterally were also observed in patients with SCD (p < 0.05). CONCLUSION. DTI shows microstructural abnormalities of various brain areas in patients with SCD.en_US
dc.identifier.doi10.2214/AJR.11.7404
dc.identifier.endpage1174en_US
dc.identifier.issn0361-803X
dc.identifier.issue5en_US
dc.identifier.pmid22528909en_US
dc.identifier.scopus2-s2.0-84860335350en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1167en_US
dc.identifier.urihttps://doi.org/10.2214/AJR.11.7404
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9138
dc.identifier.volume198en_US
dc.identifier.wosWOS:000303162800046en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Roentgen Ray Socen_US
dc.relation.ispartofAmerican Journal of Roentgenologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcorpus callosumen_US
dc.subjectcorticospinal tracten_US
dc.subjectdiffusion-tensor imagingen_US
dc.subjectfiber tractographyen_US
dc.subjectsickle cell diseaseen_US
dc.titleQuantitative Brain Diffusion-Tensor MRI Findings in Patients With Sickle Cell Diseaseen_US
dc.typeArticleen_US

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