Effects of caffeic acid phenethyl ester on renal damage in rabbits with partial ureteral obstruction

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dc.authorscopusid56251336100
dc.authorscopusid19933417600
dc.authorscopusid22937913600
dc.authorscopusid19933866500
dc.authorscopusid57214471494
dc.authorscopusid52663095800
dc.contributor.authorAkçora, Bülent
dc.contributor.authorAltu?, Muhammed Enes
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorKontaş, Tünay
dc.contributor.authorÖztürk, Atakan
dc.contributor.authorBayraktar, Suphi
dc.date.accessioned2024-09-19T15:45:23Z
dc.date.available2024-09-19T15:45:23Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObstructive urologic diseases may cause renal injury related to intensty and duration of occlusion. In experimental studies, many pharmacological agents were used to decrease the harmful effects of obstruction on kidney. This study was designed to investigate effects of caffeic acid phenethyl ester (CAPE) on the parsial ureteral obstruction in rabbits. Twenty-one New Zealand rabbits were divided randomly into 3 groups each containing 7 animals. Group 1, 2 and 3 were defined as control (sham), partially obstructed, and partially obstructed plus CAPE treatment, respectively. All animals were sacrified at the end of 3 weeks. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and myeloperoxidase (MPO) levels were measured. In addition, kidney tissues stained with Hematoxylin-eosine were evaluated using Cleasson's histopathological criteria. MDA, NO and SOD levels were not significantly different among all groups. Mean MPO levels of groups 1, 2 and 3 were 0.22±0.07 U/g protein, 0.36±0.09 U/g protein, 0.27±0.10 U/g protein respectively. A significant increase was found in group 2 when compared to group 1(p<0.05). Kidneys of group 3 were significantly protected in terms of 2 out of 9 histopathologic criteria when compared to group 2 (p<0.05). There was significant difference between group 2 and group 3 in terms 2 out of 9 histopathologic criteria (p<0.05); injury of kidneys in group 3 was less than in group 2. MDA, NO and SOD levels which are used to detect renal injury in complete ureteral obstruction model, did not show any significant difference in partial obstruction model in our study. In the light of our biochemical and histopathologic findings, we can say that CAPE treatment has a tendency to decrease the degree of renal injury in the partial obtruction model. © 2009 OMÜ Tüm Haklari Saklidir.en_US
dc.identifier.endpage168en_US
dc.identifier.issn1300-2996
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-80053651321en_US
dc.identifier.scopusquality#BAŞV!en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14644
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectHydronephrosisen_US
dc.subjectNephropathyen_US
dc.subjectObstructionen_US
dc.subjectRabbiten_US
dc.subjectUreteren_US
dc.titleEffects of caffeic acid phenethyl ester on renal damage in rabbits with partial ureteral obstructionen_US
dc.title.alternativeKismi üreter obstrüksiyonu oluşturulan tavşanlarda kafeik asit fenetil ester'in böbrek hasarlanmasi üzerine etkilerien_US
dc.typeArticleen_US

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