Ebselen, an Active Seleno-Organic Compound, Alleviates Articular Cartilage Degeneration in a Rat Model of Knee Osteoarthritis

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dc.authoridKacmaz, Filiz/0000-0002-7166-8265
dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorYurtal, Ziya
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorKacmaz, Filiz
dc.contributor.authorKalacı, Aydıner
dc.date.accessioned2024-09-18T20:52:58Z
dc.date.available2024-09-18T20:52:58Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOsteoarthritis (OA) is a prevalent articular disease mainly characterized by extracellular matrix degradation, apoptosis, and inflammation, which lead to cartilage destruction and abnormal bone metabolism. With undesirable side effects, current limited symptomatic treatments are aimed at relieving pain and improving joint mobility in patients with OA. Intra-articular (IA) hyaluronic acid (HA) injection, as a nonsurgical therapy, is commonly used in the clinical management of knee OA, but the efficacy of this therapeutic option remains controversial. Ebselen has tremendous pharmacological importance for some diseases due to its antioxidant, antiapoptotic, and anti-inflammatory features. However, there is no research examining the therapeutic effect of Ebselen in OA using the rat OA model. Therefore, we aimed to investigate the therapeutic effect of Ebselen on cartilage degeneration and its role in bone morphogenetic protein 2 (BMP2) and nuclear factor kappa B (NF-kappa B) signaling in the molecular pathogenesis of OA. We induced a knee OA model in rats with an IA injection of monosodiumiodoacetate (MIA). After the treatment of Ebselen, we evaluated its chondroprotective effects by morphological, histopathological, and immunohistochemical methods and an enzyme-linked immunosorbent assay. We report for the first time that Ebselen treatment alleviated articular cartilage degeneration in the rat knee OA model and reduced MIA-induced BMP2 and NF-kappa B expressions. In addition, our results unveiled that Ebselen decreased IL-beta and IL-6 levels but did not affect COMP levels in the rat serum. Ebselen could be a promising therapeutic drug for the prevention and treatment of OA by alleviating cartilage degeneration and regulating BMP2 and NF-kappa B expressions.en_US
dc.description.sponsorshipScientific Research Project Fund of Hatay Mustafa Kemal University [19M047]en_US
dc.description.sponsorshipThe present study is financially supported by the Scientific Research Project Fund of Hatay Mustafa Kemal University under project number: 19M047.en_US
dc.identifier.doi10.1007/s12011-022-03472-4
dc.identifier.endpage3927en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue8en_US
dc.identifier.pmid36357655en_US
dc.identifier.scopus2-s2.0-85141693745en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3919en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-022-03472-4
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11516
dc.identifier.volume201en_US
dc.identifier.wosWOS:000881601700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteoarthritisen_US
dc.subjectEbselenen_US
dc.subjectCartilage Degenerationen_US
dc.subjectMonosodium iodoacetateen_US
dc.subjectBMP2en_US
dc.subjectNF-kappa Ben_US
dc.titleEbselen, an Active Seleno-Organic Compound, Alleviates Articular Cartilage Degeneration in a Rat Model of Knee Osteoarthritisen_US
dc.typeArticleen_US

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