Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

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dc.authoridHossain, Zenat Zebin/0000-0002-6238-0323
dc.authoridHeikinheimo, Annamari/0000-0002-6559-5442
dc.authoridAlba, Patricia/0000-0002-9621-0955
dc.authoridAarestrup, Frank/0000-0002-7116-2723
dc.authoridLau, Lok Ting/0000-0001-7517-1486
dc.authoridShin, Hanseob/0000-0001-8814-3708
dc.authoridFakhraldeen, Saja/0000-0003-3919-0270
dc.contributor.authorMunk, Patrick
dc.contributor.authorBrinch, Christian
dc.contributor.authorMoller, Frederik Duus
dc.contributor.authorPetersen, Thomas N.
dc.contributor.authorHendriksen, Rene S.
dc.contributor.authorSeyfarth, Anne Mette
dc.contributor.authorKjeldgaard, Jette S.
dc.date.accessioned2024-09-18T21:03:16Z
dc.date.available2024-09-18T21:03:16Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAntimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.en_US
dc.identifier.doi10.1038/s41467-022-34312-7
dc.identifier.issn2041-1723
dc.identifier.issue1en_US
dc.identifier.pmid36456547en_US
dc.identifier.scopus2-s2.0-85143185703en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41467-022-34312-7
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13335
dc.identifier.volume13en_US
dc.identifier.wosWOS:000929940300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofNature Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEmergenceen_US
dc.subjectNetworken_US
dc.subjectColien_US
dc.titleGenomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistanceen_US
dc.typeArticleen_US

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