Interaction between carbenoxolone and valproic acid on pentylenetetrazole kindling model of epilepsy

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dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.authoridBOSTANCI, Mehmet Omer/0000-0002-2887-1073
dc.authoridACAR KARAKURT, Meryem Dilek/0000-0002-2314-8126
dc.contributor.authorSefil, Fatih
dc.contributor.authorArik, Aliye E.
dc.contributor.authorAcar, Meryem D.
dc.contributor.authorBostanci, Mehmet O.
dc.contributor.authorBagirici, Faruk
dc.contributor.authorKozan, Ramazan
dc.date.accessioned2024-09-18T20:25:17Z
dc.date.available2024-09-18T20:25:17Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractGap junctions play an important role in the synchronized neuronal discharges. The main reason of the epileptic seizures is disruption of this synchronization. Therefore, the aim of the present study is to explore the combination valproic acid with carbenoxolone in pentylenetetrazole-kindled rats. In the first set of experiments, pentylenetetrazole (35 mg/kg intraperitoneally was administered to the rats to produce the kindling and then permanent screw electrodes to record electroencephalographic signals. The kindled rats were divided into six groups. While electroencephalographic recordings received from animals, behavioral evaluation was done by an observer. The data analysis was performed using T test and Mann-Whitney U tests. The dose of 40 mg/kg carbenoxolone was the most effective in carbenoxolone treatment groups. It prevented generalized seizures by 50%, reduced seizure stage, seizure duration and spike frequency. There was no significant difference between carbenoxolone-valproic acid combination and valproic acid on any seizure parameters. The current study is the first study which shows the interaction of carbenoxolone with valproic acid in pentylenetetrazole kindling model. As a result, carbenoxolone-valproic acid combination was not more effective than the standalone use of these drugs.en_US
dc.description.sponsorshipOndokuz Mayis University Research Foundation [PYO.TIP.1904.09.010]en_US
dc.description.sponsorshipThis project was supported by the Ondokuz Mayis University Research Foundation (PYO.TIP.1904.09.010).en_US
dc.identifier.endpage10514en_US
dc.identifier.issn1940-5901
dc.identifier.issue7en_US
dc.identifier.pmid26379841en_US
dc.identifier.scopus2-s2.0-84940706414en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage10508en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10212
dc.identifier.volume8en_US
dc.identifier.wosWOS:000361557500028en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGap junctionen_US
dc.subjectcarbenoxoloneen_US
dc.subjectvalproic aciden_US
dc.subjectkindling modelen_US
dc.subjectepilepsyen_US
dc.titleInteraction between carbenoxolone and valproic acid on pentylenetetrazole kindling model of epilepsyen_US
dc.typeArticleen_US

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