Investigation of Epstein-Barr virus serology and DNA in bone marrow transplant recipients

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dc.authoridKaynar, Leylagul/0000-0002-2035-9462
dc.contributor.authorInci, M.
dc.contributor.authorGokahmetoglu, S.
dc.contributor.authorKaynar, L.
dc.contributor.authorErcal, B. D.
dc.contributor.authorDurmaz, S.
dc.contributor.authorBuyukoglan, R.
dc.date.accessioned2024-09-18T20:19:48Z
dc.date.available2024-09-18T20:19:48Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate Epstein-Barr virus (EBV) serology and EBV DNA in the patients with bone marrow transplantation. In the current study, 128 patients with bone marrow transplantation (BMT) were included in Hematology-Oncology Department of Medical Faculty, Erciyes University between June 2005 and October 2009. In order to evaluate EBV serology and DNA, 357 samples obtained from the patients were studied with enzyme-linked immunosorbent assay and real-time polymerase chain reaction (PCR). The components of EBV serology were anti-Ebstein-Barr nuclear antigen (EBNA)-1 IgG, anti-viral capsid antigen (VCA) IgG and IgM. EBV seropositivity was found in 98.4% of the samples. EBV DNA positivity was detected in 13.3% of the patients. High viral load was only seen in one patient among all the EBV DNA positivity. No patient showed any symptoms regarding EBV virus and admitted with post-transplant lymphoproliferative disease. In conclusion, for the diagnosis and follow up of EBV infections in patients with BMT, detection of EBV DNA by PCR method is also beneficial in addition to serological tests regarding EBV.en_US
dc.identifier.endpage500en_US
dc.identifier.issn1996-0808
dc.identifier.issue5en_US
dc.identifier.startpage496en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9865
dc.identifier.volume5en_US
dc.identifier.wosWOS:000293694900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Microbiology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpstein-Barr virusen_US
dc.subjectserological markersen_US
dc.subjectreal-time PCRen_US
dc.subjectbone marrow transplant recipientsen_US
dc.titleInvestigation of Epstein-Barr virus serology and DNA in bone marrow transplant recipientsen_US
dc.typeArticleen_US

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