Effects of Zinc on Intestinal Injury and Some Serum Parameters in Ethanol-Administered Rats

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dc.authoridYANARDAG, REFIYE/0000-0003-4185-4363
dc.contributor.authorArda-Pirincci, Pelin
dc.contributor.authorBilgin-Sokmen, Bahar
dc.contributor.authorYanardag, Refiye
dc.contributor.authorBolkent, Sehnaz
dc.date.accessioned2024-09-18T20:19:53Z
dc.date.available2024-09-18T20:19:53Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study was designed to determine the morphological and biochemical effects of zinc sulfate and the role of metallothionein in ethanol-induced intestinal injury. Rats received zinc sulfate (100 mg/kg/d) for 3 consecutive d, 2 h prior to the administration of ethanol by gavage. Ethanol administration caused intestinal injury as determined by increased serum lactate dehydrogenase activity, urea, creatinine, uric acid, and sialic acid levels, intestinal lipid peroxidation level, decreased serum catalase activity, intestinal glutathione level, and metallothionein expression. Zinc sulfate pretreatment of the ethanol group caused a decrease in histological damage, serum lactate dehydrogenase activity, urea, creatinine, uric acid, sialic acid levels, and intestinal lipid peroxidation level, but increases in serum catalase activity, intestinal glutathione level, and metallothionein expression. The present study indicates that zinc sulfate has a protective effect against ethanol-induced intestinal injury. In addition, the protective effect of zinc on ethanol-induced intestinal injury might be mediated by metallothionein, as well as having antioxidative potential.en_US
dc.identifier.doi10.1271/bbb.70805
dc.identifier.endpage267en_US
dc.identifier.issn0916-8451
dc.identifier.issn1347-6947
dc.identifier.issue2en_US
dc.identifier.pmid19202268en_US
dc.identifier.scopus2-s2.0-65249177236en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage260en_US
dc.identifier.urihttps://doi.org/10.1271/bbb.70805
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9932
dc.identifier.volume73en_US
dc.identifier.wosWOS:000263864500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofBioscience Biotechnology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectethanolen_US
dc.subjectintestinal injuryen_US
dc.subjectmetallothioneinen_US
dc.subjectserum parametersen_US
dc.subjectzinc sulfateen_US
dc.titleEffects of Zinc on Intestinal Injury and Some Serum Parameters in Ethanol-Administered Ratsen_US
dc.typeArticleen_US

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