Effects of hyaluronan on nitric oxide levels and superoxide dismutase activities in synovial fluid in knee osteoarthritis

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dc.contributor.authorKalacı, Aydıner
dc.contributor.authorYilmaz, H. Ramazan
dc.contributor.authorAslan, Bahadir
dc.contributor.authorSoeguet, Sadik
dc.contributor.authorYanat, Ahmet Nedim
dc.contributor.authorUz, Efkan
dc.date.accessioned2024-09-18T20:26:52Z
dc.date.available2024-09-18T20:26:52Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of the present study was to evaluate the effects of hyaluronan (HA) on nitric oxide (NO) levels and superoxide dismutase (SOD) enzyme activities in synovial fluid (SF) in the treatment of patients with knee osteoarthritis (OA). SF samples were aspirated from OA patients before the commencement of the treatment (n=23) and 6 weeks after they were treated with HA products. NO levels and SOD activities were compared between the pre- and post-treatment of OA patients and of the control group (n=10). SF NO levels were significantly higher in patients with OA before the commencement of the treatment compared with the post-treatment (p < 0.001) and the control groups. The SF SOD activity of patients before the commencement of the treatment was lower than the values in the controls and post-treatment (p < 0.001). There is no significant correlation between SF NO and SOD levels and the radiographic changes of the OA knee according to Kellgren-Lawrence grading (p > 0.05). Also, the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) pain scores and physical function scores were gradually improved. These findings made us think that SF NO was a potent mediator in cartilage damage in OA, whereas SOD was an antioxidant mediator in the same process. Exogenous HA injections might reduce the NO levels and increase SOD activities in synovial fluid. These effects also do not seem to be dependent on the radiographic grading of the OA knee. More comprehensive studies are needed to clarify a possible clinical significance of this topic, and we suggest that this is an important area for further research into new treatment options.en_US
dc.identifier.doi10.1007/s10067-006-0504-y
dc.identifier.endpage1311en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue8en_US
dc.identifier.pmid17180636en_US
dc.identifier.scopus2-s2.0-34447117501en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1306en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-006-0504-y
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10574
dc.identifier.volume26en_US
dc.identifier.wosWOS:000247783800016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthyaluronanen_US
dc.subjectknee osteoarthritisen_US
dc.subjectnitric oxideen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectsynovial fluiden_US
dc.titleEffects of hyaluronan on nitric oxide levels and superoxide dismutase activities in synovial fluid in knee osteoarthritisen_US
dc.typeArticleen_US

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