Design and evaluation of new wound dressings based on collagen-cellulose derivatives

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dc.authoridTitorencu, Irina/0000-0001-9312-5811
dc.authoridKaya, Durmus Alpaslan/0000-0003-3544-9214
dc.authoridPOPA, LACRAMIOARA/0000-0002-3139-9865
dc.authoridRosca, Ana-Maria/0000-0001-5020-1052
dc.authoridGHICA, Mihaela Violeta/0000-0001-6853-9203
dc.contributor.authorTudoroiu, Elena-Emilia
dc.contributor.authorKaya, Madalina Georgiana Albu
dc.contributor.authorTitorencu, Irina
dc.contributor.authorDinu-Pirvu, Cristina Elena
dc.contributor.authorMarin, Maria Minodora
dc.contributor.authorRosca, Ana-Maria
dc.contributor.authorPopa, Lacramioara
dc.date.accessioned2024-09-18T20:11:35Z
dc.date.available2024-09-18T20:11:35Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe purpose of this research was to design and characterize new hydrogels, respectively, their lyophilized forms, spongious matrices, based on collagen and methylcellulose or hydroxyethylcellulose to be used as wound dressings. 1.1% collagen gel was blended with 3% cellulose ethers gels in different ratios. To design the new potential dressings, we evaluated the compatibility of biopolymers through rheological and spectroscopic analyses for hydrogels, respectively spectral, morphological, goniometric, enzymatic, and thermal stability. Rheological measurements indicated that all hydrogels were pseudoplastic, a required property for their manipulation and application. Spectroscopic and spectral analyses showed the conservation of the specific triple helix structure of collagen for samples with 30% cellulose ethers. The morphological evaluation demonstrated that matrices presented hydrophilic and porous structures with proper swelling ability. The thermal and biodegradation study illustrated the increase of matrices' stability with the addition of cellulose ethers gels. Biocompatibility tests showed that none of the tested matrices had any cytotoxic effect and some compositions of collagen and methylcellulose or hydroxyethylcellulose release factors that might promote fibroblasts' proliferation and had no inhibitor effect on fibroblasts migration ability; all these results guarantee the development of a promising wound dressing based on 70% collagen gel and 30% cellulose ethers gels.en_US
dc.description.sponsorshipCarol Davila University of Medicine and Pharmacy, Bucharest, Romania [33PFE]; UEFISCDI, PN-III-Experimental Demonstration Project, Romania [PED 622/2022, PN-III-P2-2.1-PED-2021-2917, TE 149/2022, PN-III-P1-1.1-TE-2021-1344]en_US
dc.description.sponsorshipThis work was financially supported by Carol Davila University of Medicine and Pharmacy, Bucharest, Romania through Contract no. 33PFE/30.12.2021. This work was supported by UEFISCDI, PN-III-Experimental Demonstration Project, project number PED 622/2022, code PN-III-P2-2.1-PED-2021-2917, Romania, and project TE 149/2022, code PN-III-P1-1.1-TE-2021-1344.en_US
dc.identifier.doi10.1016/j.matdes.2023.112469
dc.identifier.issn0264-1275
dc.identifier.issn1873-4197
dc.identifier.scopus2-s2.0-85177167070en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.matdes.2023.112469
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8961
dc.identifier.volume236en_US
dc.identifier.wosWOS:001116308400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofMaterials & Designen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCollagenen_US
dc.subjectMethylcelluloseen_US
dc.subjectHydroxyethylcelluloseen_US
dc.subjectCompatibilityen_US
dc.subjectSpongious matrixen_US
dc.subjectWound dressingsen_US
dc.titleDesign and evaluation of new wound dressings based on collagen-cellulose derivativesen_US
dc.typeArticleen_US

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