Serum High Sensitivity C Reactive Protein and Homocysteine Levels in Patients with Mild to Moderate Psoriasis

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dc.contributor.authorBalci, Didem Didar
dc.contributor.authorYonden, Zafer
dc.contributor.authorDogramaci, Cigdem Asena
dc.contributor.authorDuran, Nizami
dc.date.accessioned2024-09-18T20:55:32Z
dc.date.available2024-09-18T20:55:32Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and Design: Psoriasis has been reported to be associated with increased cardiovascular risk profile. High sensitivity C reactive protein (hs-CRP) and homocysteine (Hcy) have been demonstrated to be novel biomarkers for subsequent cardiovascular events. The aim of the present study was to examine hs-CRP, Hcy and folic acid levels in patients with mild to moderate psoriasis vulgaris. Material and Method: Fifty one consecutive patients with mild to moderate psoriasis vulgaris and thirty two sex- and age-matched healthy controls were included in this study. After excluding factors that may affect serum Hcy levels, blood samples were obtained for hs-CRP, Hcy and folic acid determination. Lipid levels were also evaluated. Results: The mean Hcy values of the psoriasis patients was significantly higher, compared with the controls (p=0.001). There were no significant difference in hs-CRP and folic acid levels between psoriasis patients and controls (p > 0.05). The total cholesterol (TC) high density lipoprotein cholesterol (HDL C) ratio was significantly higher in patients with psoriasis than in controls (p=0.044). There was a significant relationship between Hcy level and sex in psoriasis patients. The hs-CRP values had significant positive correlation with body mass index (BMI) and TC in psoriasis patients (p < 0.05). Conclusion: Serum hs-CRP and folic acid levels did not show any significant difference between patients with mild to moderate psoriasis and controls. However, serum Hcy levels increased and inversely correlated with folic acid levels in psoriasis patients. These biomarkers could provide additional information in the evaluation of the atherosclerotic risk in psoriasis. (Turkderm 2009; 43: 53-7)en_US
dc.identifier.endpage57en_US
dc.identifier.issn2717-6398
dc.identifier.issn2651-5164
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-66449095919en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11899
dc.identifier.volume43en_US
dc.identifier.wosWOS:000266646000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkderm-Turkish Archives of Dermatology and Venerologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPsoriasisen_US
dc.subjecthigh sensitivity C reactive proteinen_US
dc.subjecthomocysteineen_US
dc.subjectfolic aciden_US
dc.subjectatherosclerosisen_US
dc.titleSerum High Sensitivity C Reactive Protein and Homocysteine Levels in Patients with Mild to Moderate Psoriasisen_US
dc.typeArticleen_US

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