Relationship between the resistance genes to quaternary ammonium compounds and antibiotic resistance in staphylococci isolated from surgical site infections

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dc.contributor.authorTemiz, Muhyittin
dc.contributor.authorDuran, Nizami
dc.contributor.authorDuran, Gulay Gulbol
dc.contributor.authorEryilmaz, Naciye
dc.contributor.authorJenedi, Kemal
dc.date.accessioned2024-09-18T20:59:12Z
dc.date.available2024-09-18T20:59:12Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: We aimed to investigate the prevalence of disinfectant resistance genes (qacA/qacB, qacC) and the aminoglycosides resistance genes [(aac(6') aph(2 ''), aph(3')-IIIa, ant(4')-Ia)] in both S. aureus and coagulase-negative staphylococcal strains (CoNS) isolated from surgical site infections. Material/Methods: Totally, 130 staphylococcal strains isolated from surgical site infections between January 2012 and February 2013 were included in the study. The PCR technique was employed to verify any presence of methicillin resistance gene (mecA), aminoglycoside resistance genes [(aac(6')/aph (2 ''), aph(3)-III a ant (4')-1a)], and disinfectant resistance genes (qacA/qacB, qacC) in staphylococci. Results: MecA gene was determined in 58 (44.6%) of 130 staphylococcal isolates. A total of 28 (73.7%) of 38 S. aureus isolates were found to be positive for the mecA gene, and 4 (12.9%) of 31 isolates sensitive to amikacin were sensitive to methicillin. Eighteen (47.4%) of 38 amikacin-resistant S. aureus isolates were found to be positive for qacA/qacB genes and 11 (8.9%) of them were positive for qacC gene. Both mecA and qacA/qacB genes were found to be positive at the same time in 19 amikacin-resistant S. aureus strains. Seven (18.4%) S. aureus isolates were determined to be positive for qacA/qacB and qacC genes. Frequency of qacA/B genes was found to be 47.4% among amikacin-resistant S. aureus strains, while qacC gene was found to be 28.9% (p<0.05). The ratio of qacA/B and qacC genes in CoNS was found to be 37.9% and 20.7%, respectively (p<0.05). Conclusions: Quaternary ammonium resistance genes were found to be positive at a remarkable ratio in the staphylococcal isolates from surgical wounds. Especially, the high rates of aminoglycosides and methicillin-resistance gene was remarkable in S. aureus isolates. Quaternary ammonium resistance genes were found to be positive.en_US
dc.identifier.endpage550en_US
dc.identifier.issn1643-3750
dc.identifier.pmid24691183en_US
dc.identifier.scopus2-s2.0-84898450280en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage544en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12446
dc.identifier.volume20en_US
dc.identifier.wosWOS:000333739700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSurgical Site Infectionsen_US
dc.subjectStaphylococcal Infectionsen_US
dc.subjectDisinfectant Resistanceen_US
dc.subjectDrug Resistanceen_US
dc.subjectMicrobial - drug effectsen_US
dc.subjectStaphylococcal Infectionsen_US
dc.titleRelationship between the resistance genes to quaternary ammonium compounds and antibiotic resistance in staphylococci isolated from surgical site infectionsen_US
dc.typeArticleen_US

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