Nasal Staphylococcus Colonization in Nursing Home Residents and Antibiotic Resistance Profiles

Basit Öğe Kaydı
dc.contributor.authorGuneri, Cansu Onlen
dc.contributor.authorGuner, Pinar Doner
dc.contributor.authorAslantas, Ozkan
dc.date.accessioned2024-09-18T20:52:48Z
dc.date.available2024-09-18T20:52:48Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Staphylococci are microorganisms that are resistant to many antibiotics. Staphylococcus epidermidis is a normal flora bacterium that has recently emerged as a nosocomial pathogen and has become a worldwide issue. The aim of the study was to determine the prevalence of coagulase negative staphylococci, Staphylococcus aureus nasal carriage, and antibiotic resistance of these bacteria in nursing home residents.Materials and Methods: This study was conducted in July 2017. Forty-six samples obtained from the nasal mucosa of the participants were cultured. The species identification was done by MALDI-TOF-MS. Disk diffusion was applied to determine the antibiotic susceptibility of isolates, and polymerase chain reaction assay was employed to identify the known antimicrobial resistance genes.Results: Staphylococci were isolated from 28 (61%) of the 46 residents. The isolates (n=29) were S. epidermidis (n=22), Staphylococcus succinus (n=4), and S. aureus (n=3). Two different strains of S. epidermidis were isolated from one participant. While methicillin-resistant S. aureus was not identified in isolates; Methicillin-resistant S. epidermidis (MRSE) was found in 43% (n=12). In addition, 68% of S. epidermidis strains were multidrug resistant (MDR) (to at least one agent in three or more antimicrobial groups other than beta-lactams). All methicillin-resistant S. epidermidis (MRSE) isolates were mecA positive. Among the MRSE isolates (n=12), the following resistance genes were found: blaZ (n=5), lnuA (n=1),tetK(n=1), ermA (n=1), aac(6')/aph(2) (n=1), and ant(4')-Ia (n=1).Conclusion: To our knowledge, multi-drug resistant MRSE was detected in nursing home residents for the first time in Turkey with this study. This result suggests that S. epidermidis could serve as a reservoir of drug resistance by persistent colonization in the nasal mucosa. Observation and molecular surveillance could be applied to limit the spread of such resistant nosocomial pathogens.en_US
dc.description.sponsorshipProf. Dr. Cemil Kreki and Prof. Dr. Azlem Aycan Kayaen_US
dc.description.sponsorshipAcknowledgment We thank Assoc. Prof. Dr. Cemil Kreki and Prof. Dr. Azlem Aycan Kaya for their contributions.en_US
dc.identifier.doi10.4274/mjima.galenos.2022.2022.44
dc.identifier.issn2147-673X
dc.identifier.scopus2-s2.0-85174639800en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.4274/mjima.galenos.2022.2022.44
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11417
dc.identifier.volume11en_US
dc.identifier.wosWOS:000948946400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofMediterranean Journal of Infection Microbes and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNursing homeen_US
dc.subjectPCRen_US
dc.subjectStaphylococcus epidermidisen_US
dc.subjectnasal floraen_US
dc.titleNasal Staphylococcus Colonization in Nursing Home Residents and Antibiotic Resistance Profilesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text
Boyut:
729.6 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu