Increased Femoral Cartilage Thickness in Patients With Klinefelter Syndrome

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dc.authoridAkgul, Ozgur/0000-0003-3012-2968
dc.authoridOzgocmen, Salih/0000-0002-4860-452X
dc.authoridBAYDILLI, NUMAN/0000-0003-1017-3653
dc.contributor.authorInci, Mehmet
dc.contributor.authorAkgul, Ozgur
dc.contributor.authorBaydilli, Numan
dc.contributor.authorEkmekcioglu, Oguz
dc.contributor.authorOzgocmen, Salih
dc.date.accessioned2024-09-18T20:28:18Z
dc.date.available2024-09-18T20:28:18Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe objective of this study was to determine femoral cartilage thickness (FCT) in patients with Klinefelter syndrome (KS), which is the most common sex chromosome disorder in men with varying degrees of androgen deficiency. This cross-sectional controlled study was conducted in a tertiary care center. Participants were 33 male patients (mean age = 36.2 years) with KS and 35 aged-matched healthy male controls (mean age = 32.9 years). Femoral condyle cartilage was measured by ultrasonography at three locations in each knee. Total testosterone, estradiol, sex hormone binding globulin, free androgen index, bioavailable testosterone, and albumin levels were measured. Femoral cartilage of patients at right and left knee lateral (3.03 and 2.99 mm), mid (3.81 and 3.74 mm), and medial (3.01 and 3.20 mm) were statistically thicker than in controls (right and left knee lateral 2.29 and 2.36 mm, mid 2.64 and 2.53 mm, medial 2.39 and 2.32 mm, respectively, p < .001). There was no significant correlation between FCT and sex hormones. In conclusion, patients with KS had thicker femoral cartilage. Relatively low testosterone levels in these patients and altered estrogen metabolism may hypothetically explain increased cartilage thickness in these patients.en_US
dc.identifier.doi10.1177/1557988312458449
dc.identifier.endpage57en_US
dc.identifier.issn1557-9883
dc.identifier.issue1en_US
dc.identifier.pmid22954555en_US
dc.identifier.scopus2-s2.0-84871317600en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.1177/1557988312458449
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10836
dc.identifier.volume7en_US
dc.identifier.wosWOS:000312305600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAmerican Journal of Mens Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKlinefelter syndromeen_US
dc.subjectcartilageen_US
dc.subjectthicknessen_US
dc.subjectultrasonographyen_US
dc.titleIncreased Femoral Cartilage Thickness in Patients With Klinefelter Syndromeen_US
dc.typeArticleen_US

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