Cell proliferation and apoptosis in canine oral papillomatosis

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dc.authoridNUHOGLU, HILMI/0000-0003-2530-2542
dc.contributor.authorKarakurt, Emin
dc.contributor.authorCoskun, Nuvit
dc.contributor.authorAydin, Ugur
dc.contributor.authorDag, Serpil
dc.contributor.authorBeytut, Enver
dc.contributor.authorAtaseven, Veysel Soydal
dc.contributor.authorYilmaz, Volkan
dc.date.accessioned2024-09-18T20:02:35Z
dc.date.available2024-09-18T20:02:35Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study was aimed at the evaluation of cell proliferation, p53 level and apoptotic index by immunohistochemical methods in canine oral papillomatosis. The study material comprised of tumor tissue samples taken from six dogs being admitted to the Pathology Department of Faculty of Veterinary Medicine, Kafkas University, Kars, Turkiye. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Cases of canine oral papillomatosis, determined to have been caused by canine papillomavirus-1, were found to have a rather high cell proliferation index. Furthermore, all cases were immunohistochemically demonstrated to carry a mutant p53 gene. Despite the mutation of p53 gene, the shift in the Bax/Bcl-2 ratio of dogs diagnosed with tumor was in favor of the pro-apoptotic Bax gene. The apoptotic mechanism was determined to occur through both the caspasedependent and caspase-independent pathways. While the lesions occupied the entire oral cavity in some cases, histopathologically, malignant transformation was not detected in any of the six cases.en_US
dc.identifier.doi10.30466/vrf.2023.1996086.3818
dc.identifier.endpage82en_US
dc.identifier.issn2008-8140
dc.identifier.issn2322-3618
dc.identifier.issue2en_US
dc.identifier.pmid38465317en_US
dc.identifier.scopus2-s2.0-85187164417en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.30466/vrf.2023.1996086.3818
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7879
dc.identifier.volume15en_US
dc.identifier.wosWOS:001167381500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUrmia Univen_US
dc.relation.ispartofVeterinary Research Forumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectPapillomatosisen_US
dc.subjectProliferationen_US
dc.subjectCanineen_US
dc.subjectp53en_US
dc.titleCell proliferation and apoptosis in canine oral papillomatosisen_US
dc.typeArticleen_US

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