Protective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in rats

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dc.authoridOzen, Oguz Aslan/0000-0003-2521-0031
dc.authoridSongur, Ahmet/0000-0002-6683-5495
dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.contributor.authorZararsiz, Ismail
dc.contributor.authorMeydan, Sedat
dc.contributor.authorSarsilmaz, Mustafa
dc.contributor.authorSongur, Ahmet
dc.contributor.authorOzen, Oguz Aslan
dc.contributor.authorSogut, Sadik
dc.date.accessioned2024-09-18T20:25:11Z
dc.date.available2024-09-18T20:25:11Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aimed to investigate changes in the cerebellum of formaldehyde-exposed rats and the effects of omega-3 fatty acids on these changes. The study involved 21 male Wistar-Albino rats which were divided into three groups. The rats in Group I comprised the control group. The rats in Group II were injected with intraperitoneal 10% formaldehyde every other day. The rats in Group III received omega-3 fatty acids daily while exposed to formaldehyde. At the end of the 14-day experimental period, all rats were killed by decapitation and the cerebellum removed. The activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), xanthine oxidase (XO), and malondialdehyde (MDA) levels were determined in cerebellum specimens by using spectrophotometric methods. In our study, levels of SOD and CAT were significantly decreased, and GSH-Px, XO, MDA levels were significantly increased in rats treated with formaldehyde compared with those of the controls. Whereas, it was seen that there was an increase in SOD and CAT enzyme activities and decrease in MDA, XO, and GSH-Px levels in rats administered to omega-3 fatty acids with exposure of formaldehyde. It was determined that exposure of formaldehyde increased free radicals in cerebellum of rats and this increase was prevented by administration of omega-3 fatty acids.en_US
dc.identifier.doi10.1177/0748233710389852
dc.identifier.endpage495en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue6en_US
dc.identifier.pmid21444354en_US
dc.identifier.scopus2-s2.0-79959801802en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage489en_US
dc.identifier.urihttps://doi.org/10.1177/0748233710389852
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10147
dc.identifier.volume27en_US
dc.identifier.wosWOS:000292205200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFormaldehydeen_US
dc.subjectomega-3 fatty acidsen_US
dc.subjectcerebellumen_US
dc.subjectraten_US
dc.titleProtective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in ratsen_US
dc.typeArticleen_US

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