Endothelin-1 and Nitric Oxide levels in exudative age-related macular degeneration

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dc.authorscopusid6701809041
dc.authorscopusid15020620800
dc.authorscopusid11142262000
dc.authorscopusid16238470800
dc.authorscopusid56816888300
dc.contributor.authorTotan, Yüksel
dc.contributor.authorKoca, Cemile
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorKeskin, U?urcan
dc.contributor.authorYi?ito?lu, Ramazan
dc.date.accessioned2024-09-19T15:41:28Z
dc.date.available2024-09-19T15:41:28Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To evaluate plasma levels of endothelin-1 (ET-1) and nitric oxide (NO) in patients with exudative age-related macular degeneration (AMD). Methods: In this study, ET-1 levels, as well as nitrite plus nitrate concentrations as an indicator of plasma NO level, were measured in the plasma of 20 subjects with exudative AMD and compared with 20 healthy age and sex matched controls. Results: Mean plasma ET-1 level was significantly higher in exudative AMD patients as compared to control subjects (0.35 ± 0.06 fmol/ml versus 0.17 ± 0.03 fmol/ml, P = 0.015). Patients with exudative AMD also showed significantly lower mean plasma levels of nitrite plus nitrate as compared to the controls (58.9 ± 2.7 ?mol/l versus 82.6 ± 5.9 ?mol/l, P = 0.001). Conclusion: Increased concentrations of ET-1 and reduced levels of NO in the plasma may suggest an imbalance between vasoconstrictor and vasodilator agents, respectively, as a reflection of endothelial dysfunction in the pathogenesis of AMD. These findings may also imply the role of vasoconstriction in exudative AMD. © 2015 Journal of Ophthalmic and Vision Research.en_US
dc.identifier.doi10.4103/2008-322X.163765
dc.identifier.endpage154en_US
dc.identifier.issn2008-2010
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84940778840en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.4103/2008-322X.163765
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14280
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Ophthalmic and Vision Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAge-related Macular Degenerationen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectEndothelin-1en_US
dc.subjectNitric Oxideen_US
dc.titleEndothelin-1 and Nitric Oxide levels in exudative age-related macular degenerationen_US
dc.typeArticleen_US

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