The frequency of slime, adhesin and methicillin resistance genes among staphylococci isolated from nasal samples of multiple sclerosis patients

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dc.contributor.authorMelek, Ismet M.
dc.contributor.authorDuran, Nizami
dc.contributor.authorDuran, Gulay G.
dc.contributor.authorDuman, Taskin
dc.contributor.authorOkuyucu, Esra
dc.date.accessioned2024-09-18T20:33:00Z
dc.date.available2024-09-18T20:33:00Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIt was aimed to determine the carriage rate of Staphylococcus aureus and the occurrence of methicillin resistance, slime and adhesin genes in staphylococcal strains isolated from the nasal cavities of multiple sclerosis (MS) patients. The presence of mecA and femA, and the genes implicated in adhesion were determined by multiplex PCR in all strains. The femA gene was detected in 46.6% of 105 MS patients. While 18.1% of isolates carried the mecA gene, 81.9% of isolates were negative for the mecA gene. The presence of icaA/icaD genes was determined in a total of 84.8% of all strains. While 85.7% of Staphylococcus epidermidis isolates were positive in terms of slime genes, this ratio was determined as 81.6% among the Staphylococcus aureus strains. The occurrence of clfA gene was determined in 29 of 49 (59.2%) S. aureus isolates. Also, 45 out of 49 (91.8%) S. aureus was found to carry the fnbA gene. The carriage rate of the cna gene was determined in 40 (81.6%) isolates among the 49 S. aureus strains. The rate of methicillin resistance gene, slime production and the frequency of adhesin genes in MS patients were also significantly higher than the healthy control population. Determination of the nasal S. aureus carriers and the virulence of these strains will be important for prediction of the MS prognosis in these patients. And treating these S. aureus carriers will be very useful in preventing MS relapses.en_US
dc.description.sponsorshipMustafa Kemal Universityen_US
dc.description.sponsorshipThis work was supported by the Research Found of Mustafa Kemal University.en_US
dc.identifier.doi10.5897/AJMR11.1230
dc.identifier.endpage5460en_US
dc.identifier.issn1996-0808
dc.identifier.issue30en_US
dc.identifier.startpage5453en_US
dc.identifier.urihttps://doi.org/10.5897/AJMR11.1230
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11262
dc.identifier.volume5en_US
dc.identifier.wosWOS:000298924100020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Microbiology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple sclerosisen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectnasal carriageen_US
dc.subjectmethicillin resistanceen_US
dc.subjectadhesinsen_US
dc.subjectslimeen_US
dc.titleThe frequency of slime, adhesin and methicillin resistance genes among staphylococci isolated from nasal samples of multiple sclerosis patientsen_US
dc.typeArticleen_US

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