Evaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytes

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dc.authoridKAYRALDIZ, Ahmet/0000-0002-5174-2165
dc.contributor.authorKayraldiz, Ahmet
dc.contributor.authorDoenbak, Lale
dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorKoeker, Esra
dc.contributor.authorGoekce, Sule
dc.date.accessioned2024-09-18T21:06:28Z
dc.date.available2024-09-18T21:06:28Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractDirithromycin antibiotic is a 14-membered lactone ring macrolide and is widely used in medicine to treat many different types of bacterial infections. In the present study, the possible genotoxicity of dirithromycin was evaluated in cultured human lymphocytes by using sister chromatid exchanges (SCEs), chromosome aberration (CA), and micronucleus (MN) tests and also cell proliferation kinetics such as mitotic index (MI), replication index (RI), and nuclear division index (NDI) were analyzed for cytotoxicity. Cell cultures were treated with four different concentrations of dirithromycin (37.75, 67.50, 125, and 250 mu g/mL) for 24 and 48 h periods. Dirithromycin significantly induced SCE and MN frequency at all concentrations in both 24 and 48 h treated cells. In addition, CA level has been markedly increased in the cells treated with almost all concentrations of dirithromycin for 24 (except 37.75 mu g/mL) and 48 h treatment periods as compared to control. However, MI, RI, and NDI values were not affected by the dirithromycin treatment (p > 0.05). The results of this study indicated that dirithromycin treatment caused genetic damage by increasing the level of cytogenetic endpoints, suggesting its genotoxic and mutagenic action on human lymphocytes in vitro.en_US
dc.description.sponsorshipResearch Fund of Kahramanmaras, Sutcu Imam University [2012/2-11M]en_US
dc.description.sponsorshipThe authors would like to thank Research Fund of Kahramanmaras, Sutcu Imam University for supporting the study (Grant no. 2012/2-11M).en_US
dc.identifier.doi10.1155/2015/535490
dc.identifier.issn1687-8191
dc.identifier.issn1687-8205
dc.identifier.pmid26576152en_US
dc.identifier.scopus2-s2.0-84946926224en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2015/535490
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13621
dc.identifier.volume2015en_US
dc.identifier.wosWOS:000214726200010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofJournal of Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMacrolide Antibioticsen_US
dc.subjectCarcinogenicityen_US
dc.subjectErythromycinen_US
dc.subjectFrequencyen_US
dc.subjectUpdateen_US
dc.titleEvaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytesen_US
dc.typeArticleen_US

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