Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Novel Thiophene-Based Chiral Ligands

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dc.contributor.authorAydin, A. E.
dc.date.accessioned2024-09-18T20:16:50Z
dc.date.available2024-09-18T20:16:50Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractChiral norephedrine-derived beta-amino alcohols with a thiophene moiety were synthesized from thiophene carbaldehydes (methyl- or ethyl-substituted) and chiral amino alcohols, such as both enantiomers of norephedrine and 2-aminopropanol. The synthesized ligands were applied to the catalytic asymmetric addition of diethylzinc to aldehydes to obtain optically active alcohols with a high conversion (92%) and excellent enantioselectivities (eeup to 99%). The highest enantioselectivity (ee99%) was obtained withp-trifluorobenzaldehyde as the substrate containing the strongly electron-acceptor CF(3)group.en_US
dc.description.sponsorshipScientific Research Commission of the Hatay Mustafa Kemal University [08F0201, 1005M0115]en_US
dc.description.sponsorshipThe research was financially supported by the Scientific Research Commission of the Hatay Mustafa Kemal University (Grant No. 08F0201 and Grant no. 1005M0115).en_US
dc.identifier.doi10.1134/S1070428020050255
dc.identifier.endpage909en_US
dc.identifier.issn1070-4280
dc.identifier.issn1608-3393
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85086862955en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage901en_US
dc.identifier.urihttps://doi.org/10.1134/S1070428020050255
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9770
dc.identifier.volume56en_US
dc.identifier.wosWOS:000543420200025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodica/Springeren_US
dc.relation.ispartofRussian Journal of Organic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectenantioselective synthesisen_US
dc.subjectchiral amino alcoholsen_US
dc.subjectthiolated amino-alcoholsen_US
dc.subject1en_US
dc.subject2-additionen_US
dc.titleEnantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Novel Thiophene-Based Chiral Ligandsen_US
dc.typeArticleen_US

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