Effect of alpha-lipoic acid on endometrial implants in an experimental rat model

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dc.authoridpinar, neslihan/0000-0001-5863-9665
dc.contributor.authorPinar, Neslihan
dc.contributor.authorKarapinar, Oya Soylu
dc.contributor.authorOEzcan, Oguzhan
dc.contributor.authorOzgur, Tumay
dc.contributor.authorBayraktar, Suphi
dc.date.accessioned2024-09-18T19:52:39Z
dc.date.available2024-09-18T19:52:39Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTo investigate the antioxidant and anti-inflammatory effects of alpha-lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre- and post-treatment. Tumor necrosis factor alpha (TNF-) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF- levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha-lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti-inflammatory effects.en_US
dc.description.sponsorshipScientific Research Office of Mustafa Kemal University [13424/2015]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Office of Mustafa Kemal University (Project no: 13424/2015).en_US
dc.identifier.doi10.1111/fcp.12293
dc.identifier.endpage512en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue5en_US
dc.identifier.pmid28429826en_US
dc.identifier.scopus2-s2.0-85019696223en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage506en_US
dc.identifier.urihttps://doi.org/10.1111/fcp.12293
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7576
dc.identifier.volume31en_US
dc.identifier.wosWOS:000409087100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalpha-lipoic aciden_US
dc.subjectendometriosisen_US
dc.subjectTASen_US
dc.subjectTNF-en_US
dc.subjectTOSen_US
dc.titleEffect of alpha-lipoic acid on endometrial implants in an experimental rat modelen_US
dc.typeArticleen_US

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