The effect of intravesical cocktail therapy combined with low-dose amitriptyline on primary bladder pain syndrome

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dc.authoridGokalp, Fatih/0000-0003-3099-3317
dc.contributor.authorAbat, Deniz
dc.contributor.authorAltunkol, Adem
dc.contributor.authorGokalp, Fatih
dc.date.accessioned2024-09-18T20:04:34Z
dc.date.available2024-09-18T20:04:34Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction and hypothesis We compared the effectiveness of intravesical combination treatment and intravesical treatment plus low-dose amitriptyline in patients with primary bladder pain syndrome (PBPS). Methods A total of 53 patients were included in the study. Demographic data, voiding frequency, nocturia, visual analog scale (VAS) scores, validated O'Leary-Sant IC Symptom Index (ICSI), and IC Problem Index (ICPI) scores and scores on the Short Form-36 (SF-36) questionnaire were collected from the patients at the beginning of the treatment, and at the 6th week and 6th month of the treatment. The patients were divided into two groups. Group 1 received intravesical treatment for 6 weeks. Group 2 received intravesical treatment plus amitriptyline at a dosage of 10 mg/day. Results The frequencies of voiding and VAS scores were significantly improved in groups 1 and 2 at the 6th week compared with pretreatment (in group 1 p < 0.001, p < 0.001, and in group 2 p < 0.001, p < 0.001 respectively). The median ICSI and ICPI scores also significantly decreased in groups 1 and 2 (in group 1 p < 0.001, p < 0.001, and in group 2 p < 0.001, p < 0.001 respectively). Scores on the dimensions of the SF-36 questionnaire were significantly improved in both groups. There was no significant change in terms of VAS, nocturia, ICSI or ICPI scores when comparing the 6th week and 6th month results in groups 1 and 2 (all p > 0.05). Only role functioning/emotional achieved a significant improvement in group 2 (p = 0.007). Conclusions Intravesical combination therapies are effective in PBPS treatment. Adding low-dose amitriptyline to intravesical therapy in patients with PBPS improves emotional status.en_US
dc.identifier.doi10.1007/s00192-021-05043-y
dc.identifier.endpage1230en_US
dc.identifier.issn0937-3462
dc.identifier.issn1433-3023
dc.identifier.issue5en_US
dc.identifier.pmid34977954en_US
dc.identifier.scopus2-s2.0-85122137206en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1225en_US
dc.identifier.urihttps://doi.org/10.1007/s00192-021-05043-y
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8248
dc.identifier.volume33en_US
dc.identifier.wosWOS:000737109300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofInternational Urogynecology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder pain syndromeen_US
dc.subjectIntravesical treatmenten_US
dc.subjectInterstitial cystitisen_US
dc.subjectEmotional statusen_US
dc.subjectAmitriptylineen_US
dc.titleThe effect of intravesical cocktail therapy combined with low-dose amitriptyline on primary bladder pain syndromeen_US
dc.typeArticleen_US

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