Prevalence, Antigenic Specificity, and Bactericidal Activity of Poultry Anti-Campylobacter Maternal Antibodies

Basit Öğe Kaydı
dc.authorscopusid7004540340
dc.authorscopusid7407969105
dc.authorscopusid6507910325
dc.authorscopusid6701364405
dc.authorscopusid7201825624
dc.authorscopusid7201546879
dc.contributor.authorSahin, Orhan
dc.contributor.authorZhang, Qijing
dc.contributor.authorMeitzler, Jerrel C.
dc.contributor.authorHarr, Brian S.
dc.contributor.authorMorishita, Teresa Y.
dc.contributor.authorMohan, R.
dc.date.accessioned2024-09-19T15:48:51Z
dc.date.available2024-09-19T15:48:51Z
dc.date.issued2001
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPoultry are considered the major reservoir for Campylobacter jejuni, a leading bacterial cause of human food-borne diarrhea. To understand the ecology of C. jejuni and develop strategies to control C. jejuni infection in the animal reservoir, we initiated studies to examine the potential role of anti-Campylobacter maternal antibodies in protecting young broiler chickens from infection by C. jejuni. Using an enzyme-linked immunosorbent assay (ELISA), the prevalence of anti-C. jejuni antibodies in breeder chickens, egg yolks, and broilers from multiple flocks of different farms were examined. High levels of antibodies to the organism were detected in serum samples of breeder chickens and in egg yolk contents. To determine the dynamics of anti-Campylobacter maternal antibody transferred from yolks to hatchlings, serum samples collected from five broiler flocks at weekly intervals from 1 to 28 or 42 days of age were also examined by ELISA, Sera from the 1-day and 7-day-old chicks showed high titers of antibodies to C. jejuni. Thereafter, antibody titers decreased substantially and were not detected during the third and fourth weeks of age. The disappearance of anti-Campylobacter maternal antibodies during 3 to 4 weeks of age coincides with the appearance of C. jejuni infections observed in many broiler chicken flocks. As shown by immunoblotting, the maternally derived antibodies recognized multiple membrane proteins of C. jejuni ranging from 19 to 107 kDa. Moreover, in vitro serum bactericidal assays showed that anti-Campylobacter maternal antibodies were active in antibody-dependent complement-mediated killing of C. jejuni. Together, these results highlight the widespread presence of functional anti-Campylobacter antibodies in the poultry production system and provide a strong rationale for further investigation of the potential role of anti-C. jejuni maternal antibodies in protecting young chickens from infection by C. jejuni.en_US
dc.identifier.doi10.1128/AEM.67.9.3951-3957.2001
dc.identifier.endpage3957en_US
dc.identifier.issn0099-2240
dc.identifier.issue9en_US
dc.identifier.pmid11525990en_US
dc.identifier.scopus2-s2.0-0035458302en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3951en_US
dc.identifier.urihttps://doi.org/10.1128/AEM.67.9.3951-3957.2001
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15331
dc.identifier.volume67en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofApplied and Environmental Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnimalsen_US
dc.subjectAntibodies, Bacterialen_US
dc.subjectAntibody Specificityen_US
dc.subjectBlood Bactericidal Activityen_US
dc.subjectCampylobacter Infectionsen_US
dc.subjectCampylobacter jejunien_US
dc.subjectChickensen_US
dc.subjectEgg Yolken_US
dc.subjectEnzyme-Linked Immunosorbent Assayen_US
dc.subjectImmunity, Maternally-Acquireden_US
dc.subjectPoultry Diseasesen_US
dc.subjectbacterium antibodyen_US
dc.subjectanimalen_US
dc.subjectanimal diseaseen_US
dc.subjectantibody specificityen_US
dc.subjectarticleen_US
dc.subjectbird diseaseen_US
dc.subjectblooden_US
dc.subjectCampylobacter jejunien_US
dc.subjectchickenen_US
dc.subjectegg yolken_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectGram negative infectionen_US
dc.subjectimmunologyen_US
dc.subjectmicrobiologyen_US
dc.subjectpassive immunizationen_US
dc.subjectserum bactericidal activityen_US
dc.titlePrevalence, Antigenic Specificity, and Bactericidal Activity of Poultry Anti-Campylobacter Maternal Antibodiesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text
Boyut:
789.41 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu