Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester on Nephrotoxicity Caused by Dichlorvos in Rats

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridzemheri, ebru/0000-0003-0247-0332
dc.authoridTOPRAK, SERHAT/0000-0003-4136-0523
dc.authoridAKDAG, ABDURRAHMAN/0000-0001-5292-8001
dc.contributor.authorCelik, Muhammet Murat
dc.contributor.authorAlp, Ayse
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorZemheri, Ebru
dc.contributor.authorOzkanli, Seyma
dc.contributor.authorErtekin, Filiz
dc.contributor.authorYaldiz, Mehmet
dc.date.accessioned2024-09-18T21:06:28Z
dc.date.available2024-09-18T21:06:28Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe protective effects of Caffeic Acid Phenethyl Ester (CAPE) and intralipid (IL) on nephrotoxicity caused by acute Dichlorvos (D) toxicity were investigated in this study. Forty-eight Wistar Albino rats were divided into 7 groups as follows: Control, D, CAPE, intralipid, D + CAPE, D + IL, and D + CAPE + IL. When compared to D group, the oxidative stress index (OSI) values were significantly lower in Control, CAPE, and D + IL + CAPE groups. When compared to D + IL + CAPE group, the TOS and OSI values were significantly higher in D group (P < 0.05). When mitotic cell counts were assessed in the renal tissues, it was found that mitotic cell count was significantly higher in the D group while it was lower in the D + CAPE, D + IL, and D + IL + CAPE groups when compared to the control group (P < 0.05). Also, immune reactivity showed increased apoptosis in D group and low profile of apoptosis in the D + CAPE group when compared to the Control group. The apoptosis level was significantly lower in D + IL + CAPE compared to D group (P < 0.05) in the kidneys. As a result, we concluded that Dichlorvos can be used either alone or in combination with CAPE and IL as supportive therapy or as facilitator for the therapeutic effect of the routine treatment in the patients presenting with pesticide poisoning.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Project Coordination [1206M0126(404)]en_US
dc.description.sponsorshipThis study with 1206M0126(404) ID number was supported by Mustafa Kemal University Scientific Research Project Coordination.en_US
dc.identifier.doi10.1155/2015/491406
dc.identifier.issn2090-8865
dc.identifier.issn2090-8873
dc.identifier.pmid26504614en_US
dc.identifier.scopus2-s2.0-84945416568en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2015/491406
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13620
dc.identifier.volume2015en_US
dc.identifier.wosWOS:000363155800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofJournal of Analytical Methods in Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetabonomic Analysisen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectEllagic Aciden_US
dc.subjectOrganophosphateen_US
dc.subjectToxicityen_US
dc.subjectExposureen_US
dc.subjectNeurotoxicityen_US
dc.subjectBrainen_US
dc.subjectQuercetinen_US
dc.titleProtective Effects of Intralipid and Caffeic Acid Phenethyl Ester on Nephrotoxicity Caused by Dichlorvos in Ratsen_US
dc.typeArticleen_US

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